Brain and behavioral evidence for altered social learning mechanisms among women with assault-related posttraumatic stress disorder

Journal of Psychiatric Research
Josh M CislerClinton D Kilts

Abstract

Current neurocircuitry models of PTSD focus on the neural mechanisms that mediate hypervigilance for threat and fear inhibition/extinction learning. Less focus has been directed towards explaining social deficits and heightened risk of revictimization observed among individuals with PTSD related to physical or sexual assault. The purpose of the present study was to foster more comprehensive theoretical models of PTSD by testing the hypothesis that assault-related PTSD is associated with behavioral impairments in a social trust and reciprocity task and corresponding alterations in the neural encoding of social learning mechanisms. Adult women with assault-related PTSD (n = 25) and control women (n = 15) completed a multi-trial trust game outside of the MRI scanner. A subset of these participants (15 with PTSD and 14 controls) also completed a social and non-social reinforcement learning task during 3T fMRI. Brain regions that encoded the computationally modeled parameters of value expectation, prediction error, and volatility (i.e., uncertainty) were defined and compared between groups. The PTSD group demonstrated slower learning rates during the trust game and social prediction errors had a lesser impact on subsequent investmen...Continue Reading

References

Aug 1, 1996·Behaviour Research and Therapy·E B BlanchardC A Forneris
Mar 11, 2000·Journal of Consulting and Clinical Psychology·D G KilpatrickP P Schnurr
Dec 26, 2001·Biological Psychiatry·L M ShinS L Rauch
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Jun 17, 2006·Nature·Nathaniel D DawRaymond J Dolan
Aug 8, 2006·Annals of the New York Academy of Sciences·Lisa M ShinRoger K Pitman
Aug 7, 2007·Nature Neuroscience·Timothy E J BehrensMatthew F S Rushworth
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jean Decety, Claus Lamm
Oct 26, 2007·Journal of Cognitive Neuroscience·Maria Ida GobbiniJames V Haxby
Nov 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom SchönbergJohn P O'Doherty
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Frank KruegerJordan Grafman
Mar 4, 2008·Journal of Psychiatric Research·Mohammed R MiladRoger K Pitman
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kerstin PreuschoffPeter Bossaerts
Mar 28, 2008·Nature Neuroscience·Matthew F S Rushworth, Timothy E J Behrens
Apr 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alan N HamptonJohn P O'Doherty
Aug 9, 2008·Behaviour Research and Therapy·Sally A MooreNiklas Mollenholt
Aug 9, 2008·Science·Brooks King-CasasP Read Montague
May 30, 2009·Science·Timothy E J BehrensMatthew F S Rushworth
Aug 12, 2009·Journal of Personality Disorders·Zsolt UnokaSzabolcs Kéri
Sep 15, 2009·Biological Psychiatry·Mohammed R MiladScott L Rauch
May 7, 2011·Clinical Psychology Review·Josh M CislerJeffrey L Willems
May 3, 2012·Journal of Interpersonal Violence·Kate WalshTerri L Messman-Moore
Jun 14, 2012·Journal of Adolescence·Stefano R BelliJennifer Y F Lau
Oct 2, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tanja JovanovicKerry J Ressler
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Jan 2, 2013·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Terri L Messman-MooreNoga Zerubavel
May 9, 2014·Psychiatry Research·Jennifer K LenowJosh M Cisler

❮ Previous
Next ❯

Citations

Aug 16, 2016·Journal of Psychiatric Research·Cynthia GillikinJeff Sanders
Aug 11, 2018·Human Brain Mapping·Running NiuQiyong Gong
Jul 26, 2018·Psychological Medicine·Victoria BellSukhi Shergill
May 2, 2019·Molecular Psychiatry·Siân E RobsonKristin K Nicodemus
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Caroline A BrowneIrwin Lucki
Oct 15, 2019·Journal of Interpersonal Violence·Kyrie SellnowJosh M Cisler
Sep 3, 2019·Frontiers in Human Neuroscience·Dominic S Fareri
Dec 5, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marisa C RossJosh M Cisler
Feb 5, 2021·Borderline Personality Disorder and Emotion Dysregulation·Johanna HeppInga Niedtfeld

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.