Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Claire AndréGéraldine Rauchs

Abstract

Sleep disturbances are increasingly recognized as a risk factor for Alzheimer's disease. However, no study has assessed the relationships between objective sleep fragmentation (SF) and brain and cognitive integrity across different cognitive stages, from cognitively unimpaired elderly subjects to patients with subjective cognitive decline and/or mild cognitive impairment. 30 cognitively unimpaired elderly participants and 36 patients with subjective cognitive decline and/or mild cognitive impairment underwent a neuropsychological evaluation, structural MRI, 18F-fluorodeoxyglucose, and 18F-florbetapir-PET scans, and an actigraphy recording over a minimum of six consecutive nights. Multiple regression and mediation analyses were performed between SF parameters, neuroimaging data, and cognitive scores. In cognitively unimpaired elderly participants, SF intensity mediated the association between frontohippocampal hypometabolism and lower executive functioning. Moreover, to a lower extent, increased SF variability was related to thalamic atrophy and ventromedial prefrontal amyloid burden. However, in patients with subjective cognitive decline and/or mild cognitive impairment, SF no longer contributed to the expression of cognitive d...Continue Reading

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Citations

Aug 25, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Maximilian BueglerIoannis Tarnanas
Oct 3, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Ashley F CurtisChristina S McCrae
Mar 2, 2021·Neural Regeneration Research·Huang KuangShu-Long Yang

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Clinical Trials Mentioned

NCT01638949

Software Mentioned

AlphaSim
MotionWare
R package “ mediation ”
SPM12

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