Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats

Prostaglandins, Leukotrienes, and Essential Fatty Acids
L UlmannJ P Poisson

Abstract

The aim of this work was to study the composition of long chain fatty acids and the n-6 and n-3 fatty acid ratios in aged and young Wistar rats in brain and hippocampus, related to relative cognitive deficits. The aged animals showed cognitive deficits during acquisition of a memory task (delayed alternation). In brain, results showed a decrease in palmitoleic and palmitic acid percentages in all the studied phospholipid classes and in the phosphatidylserine and phosphatidylcholine classes, respectively, in old rats, compared to the young ones. There was also an increase in oleic and stearic acid amounts in the sphingomyelin, phosphatidylserine and phosphatidylinositol classes and in the phosphatidylserine and phosphatidylcholine classes, respectively. Arachidonic acid amount was decreased in old rats, compared to the young ones, in the phosphatidylserine and phosphatidylinositol classes. Total n-6 and n-3 fatty acid amounts were both decreased in all phospholipid classes, with a stable n-6/n-3 ratio. Our results confirm that arachidonic acid concentration is decreased in aged rats and that this reduction, more significant in phosphatidylserine and phosphatidylinositol classes, should be related to the fact that low concentrati...Continue Reading

References

Dec 11, 1978·Journal of Chromatography·F Vitiello, J P Zanetta
Apr 1, 1983·Neurochemical Research·G CalderiniG Toffano
Aug 15, 1996·European Journal of Pharmacology·B McGahon, M A Lynch

❮ Previous
Next ❯

Citations

Sep 4, 2009·Genes & Nutrition·Lauren Meredith WillisJames A Joseph
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H Fai PoonD Allan Butterfield
May 21, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alejandro Lucas-SánchezJorge de Costa
Apr 19, 2013·Free Radical Research·C Guerra-AraizaH Salgado-Ceballos
Jul 18, 2012·Medical Hypotheses·S Yehuda
May 29, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Pedro F Almaida-PagánDouglas R Tocher
Dec 7, 2011·Progress in Lipid Research·María Dolores LedesmaCarlos G Dotti
May 4, 2006·Nutritional Neuroscience·S YehudaD I Mostofsky
Jun 9, 2004·Clinics in Geriatric Medicine·H Fai PoonD Allan Butterfield
Jul 19, 2006·Neurobiology of Aging·A L PetursdottirG V Skuladottir
Dec 4, 2012·Biochimica Et Biophysica Acta·Pushpendra SinghAmitabha Chattopadhyay
May 6, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Giuseppe Astarita, Daniele Piomelli
Jul 6, 2014·Progress in Lipid Research·Hee-Yong KimArthur A Spector
Jul 10, 2007·Biochimica Et Biophysica Acta·Soumi MukherjeeAmitabha Chattopadhyay
Jul 27, 2005·Biochimica Et Biophysica Acta·Soumi Mukherjee, Amitabha Chattopadhyay
Jul 28, 2016·Biochimica Et Biophysica Acta·S Thirupathi ReddyAmitabha Chattopadhyay
Aug 5, 2014·ACS Chemical Neuroscience·Mariana Angoa-PérezDonald M Kuhn
Feb 10, 2012·The Journal of Physical Chemistry. B·Pushpendra SinghAmitabha Chattopadhyay
Oct 30, 2016·Biochimie·Julie ColinThierry Oster
Apr 3, 2009·The American Journal of Clinical Nutrition·Lauren M WillisJames A Joseph
May 10, 2013·Bulletin of Experimental Biology and Medicine·A Yu MorozovaV P Chekhonin
Jul 31, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lei YangRuling Shi
Aug 26, 2014·Reviews in the Neurosciences·Lauren E Salminen, Robert H Paul
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ye Jin KimJae Geun Kim
Jan 13, 2004·Physiological Reviews·M A Lynch
Oct 13, 2006·Current Opinion in Gastroenterology·John E Morley
Apr 5, 2021·Zoological Science·Shengzhi YangLikou Zou
Jul 1, 2021·Acta Neuropathologica Communications·Ceren EmreMarianne Schultzberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved