Brain and memory: new neurons to remember

Biologie aujourd'hui
Alexandra GrosS Laroche

Abstract

A defining characteristic of the brain is its remarkable capacity to undergo activity-dependent functional and structural remodelling via mechanisms of plasticity that form the basis of our capacity to encode and retain memories. The prevailing model of how our brain stores new information about relationships between events or new abstract constructs suggests it resides in activity-driven modifications of synaptic strength and remodelling of neural networks brought about by cellular and molecular changes within the neurons activated during learning. To date, the idea that a form of activity-dependent synaptic plasticity known as long-term potentiation, or LTP, and the associated synaptic growth play a central role in the laying down of memories has received considerable support. Beyond this mechanism of plasticity at the synapse, adult neurogenesis, i.e. the birth and growth of new neurons, is another form of neural plasticity that occurs continuously in defined brain regions such as the dentate gyrus of the hippocampus. Here, based on work in the hippocampus, we review the processes and mechanisms of the generation and selection of new neurons in the adult brain and the accumulating evidence that supports the idea that this fo...Continue Reading

References

Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Jul 11, 1997·Brain Research·A MontkowskiF Holsboer
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Apr 9, 1999·Nature Neuroscience·E GouldT J Shors
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Apr 12, 2002·Brain Research. Developmental Brain Research·Gerd Kempermann, Fred H Gage
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joel C SelcherMichael Swank
May 3, 2002·Nature·Hongjun SongFred H Gage
May 29, 2002·Brain Research Bulletin·Fernando Nottebohm
Nov 21, 2002·Hippocampus·Tracey J ShorsElizabeth Gould
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bruno BozonSerge Laroche
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elodie DrapeauDjoher Nora Abrous
Dec 6, 2003·The European Journal of Neuroscience·Sebastian Jessberger, Gerd Kempermann
Jan 31, 2004·The European Journal of Neuroscience·T J ShorsB Leuner
Mar 31, 2004·Neuroscience Letters·Patrizia AmbroginiRiccardo Cuppini
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Jul 13, 2004·Brain Research. Developmental Brain Research·Andréanne Bédard, André Parent
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bendetta LeunerTracey J Shors
Dec 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woong SunRonald W Oppenheim
Dec 25, 2004·Behavioural Brain Research·Karin Van der BorghtEddy A Van der Zee
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Elodie Bruel-JungermanS Laroche
Journal de la Société de biologie
S Laroche
Progress in Molecular Biology and Translational Science
Alexandra VeyracS Laroche
© 2021 Meta ULC. All rights reserved