Brain and spinal cord lesion criteria distinguishes AQP4-positive neuromyelitis optica and MOG-positive disease from multiple sclerosis

Multiple Sclerosis and Related Disorders
C BensiM F Farez

Abstract

Test the ability of a brain and spinal cord MRI criteria to differentiate neuromyelitis optica spectrum disorders and MOG-disease from MS. MRI criteria was further tested in patients with CIS and pediatric MS. MOG-disease and neuromyelitis optica spectrum disorders can present clinical and radiological features strikingly similar to those of MS. Previously, diagnostic criteria based on brain MRI have been proposed to distinguish between these demyelinating diseases (Matthews-Jurynczik criteria), but spinal cord imaging and its relevance in CIS have not been evaluated. Simple brain and spinal cord MRI criteria may help separate these three inflammatory CNS diseases both in adults and children, aiding in early diagnostic decision-making, such as need for antibody testing. We included 150 participants (23 with aquaporin-4-positive neuromyelitis optica spectrum disorder, 14 with MOG-disease, 20 with aquaporin-4-negative neuromyelitis optica spectrum disorder, 48 with adult-onset relapsing remitting MS, 24 with pediatric-onset MS and 21 with clinically isolated syndrome). Brain and spinal cord MRI scans were anonymised and scored by 2 separate raters, based on two sets of criteria: one previously described by Matthews and colleagues...Continue Reading

Citations

Jan 30, 2019·Journal of Neurology·M J WendebourgR Schlaeger
Oct 1, 2019·Annals of Clinical and Translational Neurology·Meng-Ting CaiMei-Ping Ding
May 28, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Edgar Carnero ContenttiJuan Ignacio Rojas
May 28, 2020·Biomedicines·Mariano MarrodanJorge Correale
Aug 7, 2020·AJR. American Journal of Roentgenology·Mona ShahriariDavid M Yousem
Feb 27, 2021·Multiple Sclerosis and Related Disorders·Michela Ada Noris FerilliRaffaele Iorio
Jul 11, 2021·Multiple Sclerosis and Related Disorders·Tiziana CarandiniAnna Margherita Pietroboni

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