Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis

ENeurologicalSci
Akram DastagirShahamat Tauhid

Abstract

Primary progressive (PP) multiple sclerosis (MS) is considered a clinically distinct entity from the spectrum of relapsing-remitting (RR) forms of the disease. To compare the presence of brain and spinal cord lesions between PP and RR subjects. We studied people with PPMS [n = 40, 17 (42.5%) men, age 50.7 ± 7.7 years, disease duration 10.1 ± 7.4 years, Expanded Disability Status Scale (EDSS) score 4.6 ± 2.1] and RRMS [n = 40, 12 (30%) men, age 47.9 ± 4.2, disease duration 13.7 ± 5.9, EDSS 1.7 ± 1.3]. MRI of the brain and full spinal cord at 1.5T was analyzed to define patients having: 1. brain only, 2. spinal cord only, or 3. brain and spinal cord MS lesions. Lesions in the brain only were less common in PP (n = 1, 2.5% of people) than RR (n = 10, 25%) (Fisher's exact p = 0.007). Lesions in the spinal cord only (PP: n = 6, 15%, RR: n = 3, 7.5%, p = 0.481) or brain plus spinal cord (PP: n = 33, 83%, RR: n = 27, 68%, p = 0.196) were similar between groups. PP had higher EDSS and timed 25-ft walk (Wilcoxon tests, both p < 0.001), higher age (t-test p = 0.049), lower disease duration (t-test, p = 0.02), and a similar sex ratio (Fisher's exact p = 0.352) vs. RR. We report a topographic difference in MRI lesion involvement between PP...Continue Reading

Citations

Jul 2, 2020·International Journal of Molecular Sciences·Mirre De BondtSofie Struyf
Aug 27, 2019·Frontiers in Neurology·Michaela AndelovaManuela Vaneckova
Oct 19, 2020·Revue neurologique·S LeguyA Kerbrat
Aug 28, 2021·International Journal of Molecular Sciences·Rodica BalasaDoina Manu

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