Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone

Journal of Affective Disorders
Tatiana de Queiroz OliveiraSilvânia Maria Mendes Vasconcelos

Abstract

Depression is accompanied by activated neuro-oxidative and neuro-nitrosative pathways, while targeting these pathways has clinical efficacy in depression. This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations. Male mice received vehicle or CORT 20mg/kg during 14 days. From the 15th to 21st days they were divided in groups administered: vehicle, MIRT 3mg/kg or the combinations MIRT+ALA100 or MIRT+ALA200. On the 21st day of treatment, the animals were subjected to behavioral tests. Twenty-four hours after the last drug administration hippocampus (HC) and striatum (ST) were dissected for the determination reduced glutathione (GSH), lipid peroxidation (LP) and nitrite levels. CORT induced anxiety- and depressive-like behaviors as observed by increased immobility time in the tail suspension test and decreased sucrose consumption. MIRT or MIRT+ALA are effective in reversing anxiety- and depressive-like behaviors induced by CORT. CORT and MIRT alone prolonged sleeping time and this effect was reversed by MIRT+ALA. CORT significantly increased LP, which was reversed by MIRT or MIRT+ALA. Nitrite levels w...Continue Reading

References

Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication

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Citations

Jul 15, 2020·Journal of Biochemical and Molecular Toxicology·Ismet Burcu TurkyilmazRefiye Yanardag
May 23, 2020·Toxicology Mechanisms and Methods·Fatma IbrahimMohamed A Shaheen
Apr 11, 2018·Metabolic Brain Disease·Zhi-Kun QiuJi-Sheng Chen
May 2, 2021·Brain Research Bulletin·Zhiwen GengBernard Yan
Aug 15, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Gabriel A AquinoSilvânia M M Vasconcelos
Aug 21, 2021·Frontiers in Psychiatry·Lining DuanYousheng Mo

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