Brain barrier dysfunction in Cuban epidemic optic neuropathy

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
A González-Quevedo MonteagudoR Santiago Luis González

Abstract

There are practically no references to cerebrospinal fluid (CSF) studies in tropical or nutritional neuropathies. In the present paper we present the results of CSF studies in patients with Cuban Epidemic Optic Neuropathy (CEON) during epidemic and endemic periods, with an appraisal as to the contribution of brain barriers' function in the pathophysiology of this disease. Two hundred and five patients with CEON were studied during the epidemic period (1992-1993) and 12 patients outside the outbreak (1995-1997). CSF protein determination and electrophoresis were carried out, as well as serum and CSF albumin and immunoglobulin G (IgG) quantitation for calculating IgG and Q(alb) indexes, in order to evaluate intrathecal IgG synthesis and the permeability of the blood-CSF barrier (B-CSF B). One fourth of the patients had increased permeability of the B-CSF B, but damage was more frequent between 16 and 60 days from onset of disease, disappearing after 120 days. B-CSF B dysfunction was more prevalent in patients with severe neurological impairment, although it was not related to the severity of ophthalmological damage. The group of patients studied outside of the outbreak (endemic period) showed similar results. The possible associa...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J F Poduslo, G L Curran
Nov 2, 1995·The New England Journal of Medicine·UNKNOWN Cuba Neuropathy Field Investigation Team
Dec 1, 1994·Journal of the Neurological Sciences·I BorrajeroL Navarro-Román
Dec 20, 1994·Journal of the Neurological Sciences·I AlfaroR Santiesteban
Apr 20, 1994·JAMA : the Journal of the American Medical Association
Sep 1, 1996·The American Journal of Clinical Nutrition·C Macias-MatosC J Bates
Sep 1, 1996·Toxicology and Applied Pharmacology·J T EellsT G Murray
Jun 2, 1998·Free Radical Biology & Medicine·M D Noseworthy, T M Bray
Dec 16, 1998·Current Opinion in Neurology·G Román
Feb 15, 2000·Annals of the New York Academy of Sciences·K Todd, R F Butterworth
Jan 10, 2002·Journal of Toxicology. Clinical Toxicology·W Zheng
Feb 19, 2002·Neurochemistry International·Valerio CarelliAlfredo A Sadun
Apr 9, 2002·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Michael S Vaphiades, Nancy J Newman
Mar 25, 2005·Journal of Neurology·J BrettschneiderH Tumani
Mar 1, 2006·Brain : a Journal of Neurology·H E KillerA R Huber
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Bhushan M KapurPeter L Carlen

❮ Previous
Next ❯

Citations

Apr 15, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A J Dorta-Contreras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.