Brain, Behavior, and Cognitive Interplay in Disorders of Consciousness: A Multiple Case Study

Frontiers in Neurology
Charlène AubinetOlivia Gosseries

Abstract

Patients with prolonged disorders of consciousness (DoC) after severe brain injury may present residual behavioral and cognitive functions. Yet the bedside assessment of these functions is compromised by patients' multiple impairments. Standardized behavioral scales such as the Coma Recovery Scale-Revised (CRS-R) have been developed to diagnose DoC, but there is also a need for neuropsychological measurement in these patients. The Cognitive Assessment by Visual Election (CAVE) was therefore recently created. In this study, we describe five patients in minimally conscious state (MCS) or emerging from the MCS (EMCS). Their cognitive profiles, derived from the CRS-R and CAVE, are presented alongside their neuroimaging results using structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). Scores on the CAVE decreased along with the CRS-R total score, establishing a consistent behavioral/cognitive profile for each patient. Out of these five cases, the one with highest CRS-R and CAVE performance had the least extended cerebral hypometabolism. All patients showed structural and functional brain impairments that were consistent with their behavioral/cognitive profile as based on previou...Continue Reading

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Citations

Jul 24, 2020·Expert Review of Neurotherapeutics·Caroline Schnakers
Sep 3, 2019·Frontiers in Systems Neuroscience·Vincent BonhommeOlivia Gosseries
Dec 6, 2020·Brain Sciences·Caroline SchnakersAnna Estraneo

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Software Mentioned

SPM12
DARTEL
CRS
VBM8
CAVE
R

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