Brain-behavior relationship in a case of successful ECT for drug refractory catatonic OCD

The Journal of ECT
Giordano D'UrsoGiovanni Muscettola

Abstract

This case report describes the successful response to electroconvulsive therapy (ECT) in a patient with an unusual presentation of catatonia, whose onset occurred in the context of an extremely severe form of refractory obsessive-compulsive disorder (OCD). We correlated the clinical improvement in catatonic and OCD symptoms with specific changes in brain function as shown by regional cerebral blood flow scans, neurological soft signs examination, and neuropsychological testing. All assessments were conducted before and after the ECT course. The results strongly suggest that a right hemisphere dysfunction was the neural correlate of our patient's symptoms, and that ECT, by reverting this abnormality, may serve as an effective therapeutic approach for refractory catatonic OCD.

Citations

Aug 26, 2014·The Psychiatric Clinics of North America·Melisse BaisDamiaan Denys
Jul 2, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kyle A B LapidusWayne K Goodman
May 16, 2017·Journal of Affective Disorders·Giordano D'UrsoAlfredo Carlo Altamura
Feb 4, 2016·The Journal of ECT·Claudio BuccelliMassimo Niola
Jul 21, 2020·Expert Review of Neurotherapeutics·Alexis G McCathernEric A Storch

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