PMID: 8054609Mar 1, 1993

Brain bioenergetic parameters in rats with varying resistance to hypoxia

Biulleten' eksperimental'noĭ biologii i meditsiny
A M DudchenkoL D Luk'ianova

Abstract

Spontaneous electrical activity, adenyl nucleotides' and cytochromes' contents, activity of respiratory chain enzymes complex in brain slices, homogenate and isolated mitochondria of rats, preliminary divided into non-resistant (NR) and high resistant (HR) animals by their sensitivity to hypobaric hypoxia have been investigated. It has been shown that in HR animals brain slices high resistant to hypoxia neurons and in NR brain slices non-resistant neurons predominate. ATP content and energetic charge in the HR animals brain slice were maintained at more high level than in NR. The reduction of NAD-depended way of oxidation in low pO2 conditions was greater in brain of NR than in HR animals. Activity of NADH-cytochrome C reductase (rotenon-sensitive) and Km for NADH in HR brain was more higher in the comparison with NR. These data indicate the main role of NADH-oxidase way in the formation of the individual brain resistance to hypoxia.

References

Oct 31, 2007·Izvestiia Akademii nauk. Seriia biologicheskaia·A S ShtembergIu V Farber
Oct 21, 2015·Frontiers in Neuroscience·Ludmila D Lukyanova, Yulia I Kirova
Mar 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Dudchenko, L D Luk'ianova
Jan 31, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·L D Luk'ianova
Dec 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Dudchenko, L D Lukianova
Dec 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·L D Luk'ianovaV V Belousova
Oct 17, 2008·Bulletin of Experimental Biology and Medicine·L D LukyanovaI V Erenburg
Apr 17, 2010·Bulletin of Experimental Biology and Medicine·L D LukyanovaG N Chernobaeva
Feb 23, 2019·Bulletin of Experimental Biology and Medicine·L D Luk'yanovaE L Germanova

Citations

Jan 1, 1980·The International Journal of Biochemistry·M Hohenegger, H Schuh
Jan 1, 1959·Journal of Neurochemistry·R RODNIGHTM A TRESIZE

Related Concepts

Enzymes, antithrombotic
Energy Metabolism
Resting Potentials
Neurons
Brain
Oxidase
Electrical Activity of Brain
NADH
Oxidation
Cytochromes

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