PMID: 8054609Mar 1, 1993

Brain bioenergetic parameters in rats with varying resistance to hypoxia

Biulleten' eksperimental'noĭ biologii i meditsiny
A M DudchenkoL D Luk'ianova


Spontaneous electrical activity, adenyl nucleotides' and cytochromes' contents, activity of respiratory chain enzymes complex in brain slices, homogenate and isolated mitochondria of rats, preliminary divided into non-resistant (NR) and high resistant (HR) animals by their sensitivity to hypobaric hypoxia have been investigated. It has been shown that in HR animals brain slices high resistant to hypoxia neurons and in NR brain slices non-resistant neurons predominate. ATP content and energetic charge in the HR animals brain slice were maintained at more high level than in NR. The reduction of NAD-depended way of oxidation in low pO2 conditions was greater in brain of NR than in HR animals. Activity of NADH-cytochrome C reductase (rotenon-sensitive) and Km for NADH in HR brain was more higher in the comparison with NR. These data indicate the main role of NADH-oxidase way in the formation of the individual brain resistance to hypoxia.


Oct 31, 2007·Izvestiia Akademii nauk. Seriia biologicheskaia·A S ShtembergIu V Farber
Oct 21, 2015·Frontiers in Neuroscience·Ludmila D Lukyanova, Yulia I Kirova
Mar 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Dudchenko, L D Luk'ianova
Jan 31, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·L D Luk'ianova
Dec 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Dudchenko, L D Lukianova
Dec 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·L D Luk'ianovaV V Belousova
Oct 17, 2008·Bulletin of Experimental Biology and Medicine·L D LukyanovaI V Erenburg
Apr 17, 2010·Bulletin of Experimental Biology and Medicine·L D LukyanovaG N Chernobaeva
Feb 23, 2019·Bulletin of Experimental Biology and Medicine·L D Luk'yanovaE L Germanova


Jan 1, 1980·The International Journal of Biochemistry·M Hohenegger, H Schuh
Jan 1, 1959·Journal of Neurochemistry·R RODNIGHTM A TRESIZE

Related Concepts

Enzymes, antithrombotic
Energy Metabolism
Resting Potentials
Electrical Activity of Brain

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.