Brain cancer stem-like cells

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Toru Kondo

Abstract

Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Moreover, many tumours and cancer cell lines express stem cell markers, including adenosine triphosphate (ATP)-binding cassette transporters, by which the cells pump out specific fluorescent dyes as well as anti-cancer drugs, suggesting either that cancer cells resemble stem cells or that cancers contain stem-like cells. Using the common characteristics of brain tumour cells and neural stem cells, several research groups have succeeded in identifying stem-like cells (cancer stem-like cells) in brain tumours and brain cancer cell lines. The purified cancer stem-like cells, but not the other cancer cells, self-renew and form tumours when transplanted in vivo. Thus, cancer stem-like cells in brain tumours might be a crucial target for anti-brain tumour therapy.

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Citations

Jul 19, 2008·Molecular and Cellular Biochemistry·Luci BavarescoAna Maria Oliveira Battastini
May 9, 2008·Advances in Therapy·Jian-Min LiuXiu-Jie Wang
Jun 16, 2010·Cellular and Molecular Life Sciences : CMLS·M F ShiX Xie
Sep 14, 2012·Journal of Oncology·Felipe de Almeida SassiAna Lucia Abujamra
Jun 24, 2010·Molecular Carcinogenesis·Mahshid MalakootianAfsaneh Malekzadeh Shafaroudi
Apr 2, 2011·Cancer Science·Tatsuya TakezakiToru Kondo
Mar 3, 2009·Surgical Neurology·Yu YaoLiangfu Zhou
Sep 18, 2007·Biochimica Et Biophysica Acta·Reto SutterSilvia Marino
Jan 25, 2017·Brain Tumor Pathology·Toru Kondo
Jun 26, 2020·Cancers·Kambiz AfrasiabiYi-Hong Zhou
Jul 18, 2009·Molecular Cancer Research : MCR·Guido Frosina

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