Brain cell microenvironment effects on neuron excitability and basal metabolism

Neuroreport
G L Aiello, P Bach-y-Rita

Abstract

In a model of neurons in a brain cell assembly, changes in volume of the extracellular space affect neuronal excitability and basal metabolism. A widely applicable coefficient of excitability with respect to a variation of the volume fraction has been determined. Calculations suggest that chloride increases membrane stability by indirectly promoting an acceleration of the metabolic pumping rate as a response to a diminished extracellular volume fraction. Volume fraction changes induced by cell swelling in a compact and highly tortuous microenvironment may play a role in epilepsy and, following brain damage, in cell death and recovery.

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Citations

Nov 21, 2000·Journal of Neuroscience Methods·G L Aiello, P Bach-y-Rita
May 14, 1999·Trends in Pharmacological Sciences·M ZoliK Fuxe
May 13, 2004·Journal of Integrative Neuroscience·Stephen W Kercel
Jul 1, 2005·Journal of Integrative Neuroscience·Paul Bach-Y-Rita
Jul 10, 2003·Brain Injury : [BI]·Paul Bach-y-Rita
Aug 15, 2003·Archives of Physical Medicine and Rehabilitation·Paul Bach-y-Rita
Oct 3, 2003·Topics in Stroke Rehabilitation·P Bach-y-Rita
Dec 31, 2005·Journal of Integrative Neuroscience·Laurent Renier, Anne G De Volder

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