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Brain cell type-specific enhancer-promoter interactome maps and disease- risk association

Science

Nov 29, 2019

Alexi NottChristopher K. Glass

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Abstract

Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with brain diseases, we defined noncoding regulatory regions for major cell types of the human brain. Whereas psy...read more

Mentioned in this Paper

Alzheimer's Disease
Astrocytes
Mental Disorders
Brain
Brain Diseases
Gene Deletion
Genes
Neurons
Transcription, Genetic
Promoter
120
8
3
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Brain cell type-specific enhancer-promoter interactome maps and disease- risk association

Science

Nov 29, 2019

Alexi NottChristopher K. Glass

PMID: 31727856

DOI: 10.1126/science.aay0793

Abstract

Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with brain diseases, we defined noncoding regulatory regions for major cell types of the human brain. Whereas psy...read more

Mentioned in this Paper

Alzheimer's Disease
Astrocytes
Mental Disorders
Brain
Brain Diseases
120
8
3

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Paper Details
References
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