Brain Ceramide Metabolism in the Control of Energy Balance

Frontiers in Physiology
Céline Cruciani-GuglielmacciHervé Le Stunff

Abstract

The regulation of energy balance by the central nervous system (CNS) is a key actor of energy homeostasis in mammals, and deregulations of the fine mechanisms of nutrient sensing in the brain could lead to several metabolic diseases such as obesity and type 2 diabetes (T2D). Indeed, while neuronal activity primarily relies on glucose (lactate, pyruvate), the brain expresses at high level enzymes responsible for the transport, utilization and storage of lipids. It has been demonstrated that discrete neuronal networks in the hypothalamus have the ability to detect variation of circulating long chain fatty acids (FA) to regulate food intake and peripheral glucose metabolism. During a chronic lipid excess situation, this physiological lipid sensing is impaired contributing to type 2 diabetes in predisposed subjects. Recently, different studies suggested that ceramides levels could be involved in the regulation of energy balance in both hypothalamic and extra-hypothalamic areas. Moreover, under lipotoxic conditions, these ceramides could play a role in the dysregulation of glucose homeostasis. In this review we aimed at describing the potential role of ceramides metabolism in the brain in the physiological and pathophysiological con...Continue Reading

References

Apr 1, 1975·Physiology & Behavior·Y OomuraY Yamada
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P H WeinstockJ L Breslow
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Oct 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhiyuan HuM Daniel Lane
Dec 20, 2003·Nature·Kentaro HanadaMasahiro Nishijima
Jan 27, 2004·The Journal of Biological Chemistry·Ulrika AnderssonCaroline J Small
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Mar 1, 2005·Nature Medicine·Tony K T LamLuciano Rossetti
Jun 15, 2005·Annual Review of Biochemistry·Paul DowellM Daniel Lane
Aug 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Richard JennemannHermann-Josef Gröne
May 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael J WolfgangM Daniel Lane
Jun 24, 2006·The Journal of Biological Chemistry·Yael Pewzner-JungAnthony H Futerman
Feb 14, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Miguel LópezAntonio Vidal-Puig
Aug 3, 2007·The Journal of Clinical Investigation·Marc ClaretDominic J Withers
Aug 19, 2007·The Journal of Clinical Investigation·Manu V ChakravarthyClay F Semenkovich
Aug 25, 2007·Brain : a Journal of Neurology·Ekaterina V IlievaManuel Portero-Otín
Nov 23, 2007·Current Opinion in Pharmacology·Terry L DavidsonStephen C Benoit
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J WolfgangM Daniel Lane
Jan 15, 2008·The Journal of Biological Chemistry·Adriana Y SierraNúria Casals
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Feb 16, 2008·Endocrinology·Susan A FarrJohn E Morley
May 8, 2008·Cell Metabolism·Miguel LópezAntonio Vidal-Puig
Nov 4, 2008·Trends in Molecular Medicine·Ricardo LageMiguel López
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Stephen C Woods, David A D'Alessio
Apr 14, 2009·The Journal of Clinical Investigation·Hélène L KammounFabienne Foufelle
Dec 2, 2009·Biochimica Et Biophysica Acta·Roger H UngerLelio Orci
Dec 17, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Parveen Yaqoob, Saame Raza Shaikh
Jan 9, 2010·Biochimica Et Biophysica Acta·Sam Virtue, Antonio Vidal-Puig
May 27, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Johannes KornhuberErich Gulbins
Aug 31, 2010·Nature Medicine·Miguel LópezAntonio Vidal-Puig
Sep 3, 2010·PLoS Biology·Pablo Blanco Martínez de Morentin, Miguel López
Sep 24, 2010·Nature Reviews. Molecular Cell Biology·Kai Simons, Mathias J Gerl
May 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Su GaoGary D Lopaschuk

❮ Previous
Next ❯

Citations

Mar 7, 2018·Scientific Reports·M Carmen CrespoFrancesco Visioli
Jan 24, 2019·International Journal of Molecular Sciences·Angel CogolludoLaura Moreno
Apr 20, 2019·Frontiers in Neuroscience·Nicoletta PlotegherLaura Civiero
Aug 21, 2019·International Journal of Molecular Sciences·Valentina VozellaDaniele Piomelli
Nov 7, 2019·Neuroscience·Nathalia R DraganoLicio A Velloso
Feb 6, 2021·Nutritional Neuroscience·María RodríguezCarmen Arribas
Oct 21, 2020·Cell Metabolism·Violeta HerasManuel Tena-Sempere
Jun 3, 2021·International Journal of Molecular Sciences·Andressa ReginatoAdriana Souza Torsoni
Jul 3, 2021·Biomolecules·Antía CustodiaAlberto Ouro
Oct 6, 2021·Scientific Reports·Gianluca SighinolfiBoutayna Rhourri-Frih

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuroendocrinology
Ismael González-GarcíaMiguel López
Diabetes & Metabolism
S MigrenneCéline Cruciani-Guglielmacci
© 2022 Meta ULC. All rights reserved