PMID: 58975Jun 14, 1976

Brain changes in newborns, infants and children with congenital heart disease in association with cardiac surgery. Additional observations

Journal of Neurology
K L Terplan

Abstract

The histopathologic pattern in the Central Nervous System in 12 out of 21 new-borns and young infants, below 2 months of age, operated for various congenital heart defects, is that of recent necroses in the deep and subcortical white matter of the pallium, seen from a few hours to 8 days following completion of surgery. Type and location of these lesions of ischemic coagulative necrosis, resembling findings in the perinatal respiratory distress syndrome, seem to depend on shock-like states, the low output syndrome of the left heart with hypovolemia and hypotension. The cause of death in all these infants was cardio-respiratory failure. The question to what extent glial scars replacing necroses within the mostly non-myelinated fiber systems of the pallium will lead to defective maturation of the brain in later infancy and childhood remains a challenge for neurologic and psychological investigation, even if the heart defect has been successfully repaired by the surgeon. Post-mortem data of the CNS in 24 older infants and children below 9 years of age in association with cardia surgery include thrombembolic infarctions, also, after catheterization alone, diffuse or segmental cortical necroses, and cortical scars, especially in chi...Continue Reading

References

Sep 7, 1973·The American Journal of Cardiology·C PhornphutkulW Berenberg
May 25, 1970·JAMA : the Journal of the American Medical Association·H M TufoR Shekelle
Nov 1, 1962·Archives of Neurology·B Q BANKER, J C LARROCHE

Citations

Feb 1, 1982·Journal of Steroid Biochemistry·L KornelW J Raynor
Apr 1, 1995·Pediatric Neurology·A J du PlessisJ E Mayer
Aug 1, 1996·New Horizons : an Official Publication of the Society of Critical Care Medicine·P Toltzis, J L Blumer
Dec 26, 2001·Current Opinion in Pediatrics·J K Lynch, K B Nelson
Nov 1, 1991·Pediatric Pathology·T MitoL E Becker
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J-C BecherB Wyatt
Mar 31, 1999·Seminars in Pediatric Neurology·A J du Plessis
May 9, 2009·Journal of the American College of Cardiology·Ralph Mosca
Jan 19, 2006·Circulation·J W Newburger, D C Bellinger
Feb 1, 1995·Developmental Medicine and Child Neurology·W J KupskyC F Barlow

Related Concepts

Brain
Gliosis
Congenital Heart Defects
Cardiac Surgery Procedures
Necrosis
Thromboembolism

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