Brain cholesterol turnover required for geranylgeraniol production and learning in mice

Proceedings of the National Academy of Sciences of the United States of America
Tiina KottiD W Russell

Abstract

The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme cholesterol 24-hydroxylase, and this depletion activates the mevalonate pathway. Brains from mice lacking 24-hydroxylase excrete cholesterol more slowly, and the tissue compensates by suppressing the mevalonate pathway. Here we report that this suppression causes a defect in learning. 24-Hydroxylase knockout mice exhibit severe deficiencies in spatial, associative, and motor learning, and in hippocampal long-term potentiation (LTP). Acute treatment of wild-type hippocampal slices with an inhibitor of the mevalonate pathway (a statin) also impairs LTP. The effects of statin treatment and genetic elimination of 24-hydroxylase on LTP are reversed by a 20-min treatment with geranylgeraniol but not by cholesterol. We conclude that cholesterol turnover in brain activates the mevalonate pathway and that a constant production of geranylgeraniol in a small subset of neurons is required for LTP and learning.

Associated Clinical Trials

Oct 16, 2018·Irina Pikuleva, PhD

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Citations

Mar 7, 2009·Nature Medicine·Masahisa KatsunoGen Sobue
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Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tiina KottiDavid W Russell
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