Brain correlates of progressive olfactory loss in Parkinson's disease

Parkinsonism & Related Disorders
Anna CampabadalCarme Junque

Abstract

Olfactory dysfunction is present in a large proportion of patients with Parkinson's disease (PD) upon diagnosis. However, its progression over time has been poorly investigated. The few available longitudinal studies lack control groups or MRI data. To investigate the olfactory changes and their structural correlates in non-demented PD over a four-year follow-up. We assessed olfactory function in a sample of 25 PD patients and 24 normal controls of similar age using the University of Pennsylvania Smell Identification test (UPSIT). Structural magnetic resonance imaging data, obtained with a 3-T Siemens Trio scanner, were analyzed using FreeSurfer software. Analysis of variance showed significant group (F = 53.882; P < 0.001) and time (F = 6.203; P = 0.016) effects, but the group-by-time interaction was not statistically significant. UPSIT performance declined ≥1.5 standard deviations in 5 controls and 7 patients. Change in UPSIT scores of patients correlated positively with volume change in the left putamen, right thalamus, and right caudate nucleus. Olfactory loss over time in PD and controls is similar, but we have observed significant correlation between this loss and basal ganglia volumes only in patients.

Citations

Nov 18, 2017·Nucleic Acids Research·Domenica MarcheseUNKNOWN Catalan MSA Registry (CMSAR)
Sep 19, 2019·Brain Topography·Pengfei HanThomas Hummel
Oct 4, 2018·Current Neurology and Neuroscience Reports·Jing YangDavid E Vaillancourt
Aug 17, 2020·Scientific Reports· RahulYasir Hasan Siddique
Jul 15, 2018·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·A CampabadalC Junque
Nov 21, 2019·Journal of Alzheimer's Disease : JAD·Mahraz Parvand, Catharine H Rankin
Jun 17, 2020·Journal of Parkinson's Disease·Mechelle M LewisXuemei Huang
May 21, 2021·Journal of Neural Transmission·Jae Jung LeeJong Sam Baik
Jun 8, 2021·Topics in Magnetic Resonance Imaging : TMRI·Israel Saramago, Ana M Franceschi

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