Brain cortical thickness in male adolescents with serious substance use and conduct problems

The American Journal of Drug and Alcohol Abuse
Serhiy Y ChumachenkoThomas J Crowley

Abstract

Adolescents with substance use disorder (SUD) and conduct problems exhibit high levels of impulsivity and poor self-control. Limited work to date tests for brain cortical thickness differences in these youths. To investigate differences in cortical thickness between adolescents with substance use and conduct problems and controls. We recruited 25 male adolescents with SUD, and 19 male adolescent controls, and completed structural 3T magnetic resonance brain imaging. Using the surface-based morphometry software FreeSurfer, we completed region-of-interest (ROI) analyses for group cortical thickness differences in left, and separately right, inferior frontal gyrus (IFG), orbitofrontal cortex (OFC) and insula. Using FreeSurfer, we completed whole-cerebrum analyses of group differences in cortical thickness. Versus controls, the SUD group showed no cortical thickness differences in ROI analyses. Controlling for age and IQ, no regions with cortical thickness differences were found using whole-cerebrum analyses (though secondary analyses co-varying IQ and whole-cerebrum cortical thickness yielded a between-group cortical thickness difference in the left posterior cingulate/precuneus). Secondary findings showed that the SUD group, rela...Continue Reading

References

Nov 1, 1990·Pediatric Neurology·J B Bodensteiner, G B Schaefer
Jul 8, 1988·Science·P Rakic
Apr 1, 1995·Drug and Alcohol Dependence·L B CottlerJ Hughes
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
May 20, 1999·Biological Psychiatry·R W McCarleyM E Shenton
Oct 26, 1999·Archives of General Psychiatry·R F Krueger
Apr 6, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·T J CrowleyM J MacDonald
Jul 27, 2001·Psychiatry Research·R E BlantonA W Toga
Dec 26, 2001·Biological Psychiatry·V G CarrionA L Reiss
Oct 5, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Leanne TammAllan L Reiss
Jun 5, 2003·The American Journal of Psychiatry·Ralph E TarterDuncan Clark
Aug 24, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Joseph T SakaiThomas J Crowley
Sep 8, 2004·Archives of General Psychiatry·Brian M HicksChristopher J Patrick
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Richard J RoseJaakko Kaprio
Jun 3, 2005·The American Journal of Psychiatry·Matt McGue, William G Iacono
Jul 22, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·David M FergussonElizabeth M Ridder
Sep 7, 2005·Archives of General Psychiatry·Michael C StallingsThomas J Crowley
Nov 4, 2005·Cerebral Cortex·E LudersA W Toga
Jul 21, 2006·Psychological Medicine·Frederick S StinsonBridget F Grant
Nov 15, 2006·Journal of Abnormal Psychology·Karestan C KoenenAlan Taylor
Nov 23, 2006·Cerebral Cortex·Katherine L NarrRobert M Bilder
Jan 1, 1991·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·J D AchenbachJ G Harris
Feb 28, 2008·Alcoholism, Clinical and Experimental Research·Krista Lisdahl MedinaSusan F Tapert
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Adrian Raine, Yaling Yang
Mar 21, 2009·Cerebral Cortex·Matthew S PanizzonWilliam S Kremen
Mar 24, 2010·Current Opinion in Psychiatry·Junichi Chikazoe
Nov 13, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Simone G Shamay-Tsoory
Dec 4, 2010·Annual Review of Psychology·Raymond A Mar

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Citations

Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Marisa M SilveriJennifer T Sneider
Mar 6, 2018·Current Addiction Reports·Katina C CalakosKelly P Cosgrove
Jul 12, 2017·Cognitive, Affective & Behavioral Neuroscience·Meenal BudhirajaSheilagh Hodgins
Nov 25, 2020·The American Journal on Addictions·Hyuntaek OhRamiro Salas

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