Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats

Epilepsy Research
D HoltzmanF Jensen

Abstract

Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [31P] nuclear magnetic resonance spectroscopy ([31P]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats. The CK rate constants measured before seizures were three times higher in the older than in the younger rats. The rate constants increased 60% during seizures in the older rats but did not change or decreased in the younger. Small decreases in PCr were seen during seizures at both ages. A small decrease in ATP was seen at 7 days but not at 21 days.

References

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Citations

Dec 13, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sayed Shahaboddin TabatabaeiJohan Lokk
Mar 20, 2004·Journal of Pharmaceutical and Biomedical Analysis·Nigel J C BaileyElaine Holmes
Feb 11, 2003·Epilepsy Research·Marc YudkoffItzhak Nissim
Jun 13, 2002·Epilepsia·Anne C Van Cott
Jul 21, 2009·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Richard A Marasco, R Eugene Ramsay
Nov 17, 2009·Neurochemistry International·Stacey Carmody, Lorraine Brennan
Oct 7, 2006·Biochimica Et Biophysica Acta·Valentina CecariniJeffrey N Keller
Apr 17, 2010·Neurochemistry International·Estela Natacha Brandt BusanelloMoacir Wajner
Feb 6, 2014·Acta Neurologica Scandinavica·H StefanF Kerling
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk

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