PMID: 6407769Jan 1, 1983Paper

Brain, CSF, and tumor pharmacokinetics of alpha-difluoromethylornithine in rats and dogs

Cancer Chemotherapy and Pharmacology
V A LevinD J Byrd

Abstract

We have determined the pharmacokinetic parameters for diffusion of alpha-[5-14C]-difluoromethylornithine (DFMO) from blood to brain, blood to cerebrospinal fluid (CSF), 9L rat brain tumor to adjacent brain, and blood to the subcutaneously-implanted 9L tumor in rats, and within the CSF of beagle dogs. DFMO diffusion across the blood-brain and blood-CSF barriers is quite restricted in both rats and dogs, but diffusion across the defective capillary system of both subcutaneous and intracerebral 9L tumors in rats is not. Under steady-state plasma conditions in rats, uptake of DFMO by the intracerebral 9L tumor and diffusion from tumor 5-6 mm into adjacent brain is not restricted; tissue/plasma ratios were approximately 1. Therapeutic efficacy will therefore not be limited by transport of DFMO into tumor or to the extracellular environment of tumor.

Citations

Jan 1, 1984·Cancer Chemotherapy and Pharmacology·V A LevinJ K Borcich
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·V A LevinM Prados
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·A CourdiC M Lalanne
Jan 1, 1995·Journal of Neuro-oncology·E S RedgateM Deutsch
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Van NieuwenhoveA Sjoerdsma
Jul 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·F MilordJ Pépin
Jul 10, 2007·British Journal of Pharmacology·M P BarrettR R Tidwell
Aug 1, 1985·Journal of Pharmacokinetics and Biopharmaceutics·V A Levin, H D Landahl
Feb 24, 2018·Neuro-oncology·Victor A Levin, Benjamin M Ellingson
Oct 1, 1984·Regulatory Peptides·O Benrezzak, J Morisset
Jul 13, 2021·PLoS Neglected Tropical Diseases·Mikael BobergMichael Ashton

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