Brain damage in neonatal rats following kaolin induction of hydrocephalus

Experimental Neurology
Osaama H KhanMarc R Del Bigio

Abstract

Neonatal and congenital hydrocephalus are common problems in humans. Hydrocephalus was induced in 1-day-old rats by injection of kaolin into the cisterna magna. At 7 and 21 days, magnetic resonance (MR) imaging was used to assess ventricle size, then brains were subjected to histopathological and biochemical analyses. Hydrocephalic pups did not exhibit delays in righting or negative geotaxis reflexes during the first week. At 7 days, there was variable ventricular enlargement with periventricular white matter edema, axon damage, reactive astrogliosis, and accumulation of macrophages in severe but not mild hydrocephalus. Cellular proliferation in the subependymal zone was significantly reduced. The cortical subplate neuron layer was disrupted. In rats allowed to survive to 21 days, weight was significantly lower in severely hydrocephalic rats. They also exhibited impaired memory in the Morris water maze test. Despite abnormal posture, there was minimal quantitative impairment of walking ability on a rotating cylinder. At 21 days, histological studies showed reduced corpus callosum thickness, fewer mature oligodendrocytes, damaged axons, and astroglial/microglial reaction. Reduced myelin basic protein, increased glial fibrillary ...Continue Reading

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Nov 1, 1975·Animal Behaviour·J Altman, K Sudarshan
Jan 1, 1988·Experimental Pathology·J E BruniT V Persaud
Jul 1, 1988·Neuropathology and Applied Neurobiology·H C Jones, R M Bucknall
Nov 1, 1985·Journal of Neurosurgery·J P McAllisterR C Truex
Jan 1, 1993·Acta Neuropathologica·M R Del Bigio
Sep 18, 1997·Journal of Neuropathology and Experimental Neurology·M R Del BigioY W Zhang
Mar 13, 1998·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·D HawkinsJ A Miyan
Oct 12, 2000·The Journal of Comparative Neurology·R T RobertsonJ Yu
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P C BarradasE G Moura
May 17, 2001·Journal of Neurosurgery·M R Del Bigio, E M Massicotte
Apr 6, 2002·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·T Erhan CosanEsref Tel
Jul 24, 2002·Brain : a Journal of Neurology·Farhad MashayekhiJaleel A Miyan
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Fumiaki MoriKoichi Wakabayashi
Feb 5, 2003·Brain : a Journal of Neurology·P Jane Owen-LynchJaleel A Miyan
Feb 26, 2003·Annals of Neurology·Marc R Del BigioTerry Enno
Mar 7, 2003·Pediatric Research·Osaama H KhanMarc R Del Bigio
May 29, 2004·Brain & Development·Norbert UlfigPayam Rezaie
Oct 12, 2004·Experimental Neurology·Hazel C JonesBarbara J Carter
Nov 8, 2005·Experimental Neurology·Janani BalasubramaniamMarc R Del Bigio

❮ Previous
Next ❯

Citations

Aug 19, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramin EskandariJames P McAllister
Mar 1, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Derya Burcu HazerTunçalp Ozgen
Aug 29, 2013·Brain : a Journal of Neurology·Hannah BotfieldAnn Logan
Dec 12, 2012·BMC Neuroscience·Hao XuZhanxiang Wang
Sep 27, 2007·Cerebrospinal Fluid Research·Ili SlobodianMarc R Del Bigio
Jul 12, 2008·Cerebrospinal Fluid Research·Marc R Del Bigio, Terry L Enno
May 28, 2009·Cerebrospinal Fluid Research·Kelley E DerenJames P McAllister
Nov 9, 2010·Cerebrospinal Fluid Research·Weihong YuanFrancesco T Mangano
May 29, 2010·Cerebrospinal Fluid Research·James P McAllister, Janet M Miller
Sep 4, 2012·Fluids and Barriers of the CNS·Funmilayo Eniola OlopadeAnna-Leena Sirén
Jul 3, 2010·Journal of Neurosurgery. Pediatrics·Jason G MandellSteven J Schiff
Aug 14, 2012·Journal of Neurosurgery. Pediatrics·Sukhraaj BasatiAndreas Linninger
May 10, 2008·Journal of Neurosurgery·Kristian AquilinaMarianne Thoresen
May 10, 2008·Journal of Neurosurgery·Michael A WilliamsGiovanna Spinella
Mar 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael T WilliamsWeihong Yuan
Jul 30, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramin EskandariJames P McAllister
Oct 18, 2014·Fluids and Barriers of the CNS·Domenico L Di CurzioMarc R Del Bigio
Aug 8, 2009·AJNR. American Journal of Neuroradiology·W YuanK Bierbrauer
Aug 18, 2012·AJNR. American Journal of Neuroradiology·W YuanF T Mangano
Feb 26, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Marcelo Volpon SantosRicardo Santos de Oliveira
Jul 18, 2012·Seminars in Fetal & Neonatal Medicine·James P McAllister
Jan 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marcel Levy NogueiraLaurent Schwartz
Aug 18, 2010·Experimental Neurology·Kelley E DerenJames P McAllister
Oct 20, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jinping ZhaoHope A Weiler
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Marc R Del BigioPackiasamy A R Juliet
May 23, 2009·Experimental Neurology·Luiza da Silva LopesMarc R Del Bigio
Nov 11, 2014·Journal of Neuropathology and Experimental Neurology·Tsang-Wei TuJoseph A Frank
Apr 19, 2008·Journal of Neurochemistry·Daniel KondziellaCarsten Wikkelso
Feb 1, 2012·Neuropathology and Applied Neurobiology·P S PahlavanM R Del Bigio
Mar 17, 2010·Journal of Clinical Ultrasound : JCU·Ira AdlerAlan Leviton
Apr 27, 2010·Developmental Disabilities Research Reviews·Marc R Del Bigio
May 27, 2010·IEEE Transactions on Bio-medical Engineering·Sukhraaj S BasatiAndreas A Linninger
Oct 7, 2015·Frontiers in Oncology·Marcel Levy NogueiraLaurent Schwartz
Jan 31, 2015·Journal of Neurosurgery. Pediatrics·Victoria J WilliamsJack M Fletcher
May 21, 2016·Journal of Neurosurgery. Pediatrics·Francesco T ManganoWeihong Yuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic right ventricular dysplasia is a congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the right ventricle wall and loss of myocardial cells. Primary injuries usually are at the free wall of the right ventricular and right atria resulting in ventricular and supraventricular arrhythmias. Discover the latest research on arrhythmogenic right ventricular dysplasia here.