PMID: 8957391Dec 1, 1996Paper

Brain death further promotes ischemic reperfusion injury of the rabbit myocardium

The Annals of Thoracic Surgery
S S BiswasP Van Trigt

Abstract

Little is known about preload-dependent cardiac function after brain death (BD) and subsequent graft preservation. A validated model of BD in rabbits was developed and myocardial performance was studied after BD induction and 1 hour of subsequent global hypothermic ischemia using a validated rabbit model and an isolated work-performing heart preparation. Significant decreases in stroke work, left ventricular contractility, and left ventricular relaxation were observed 2 hours after BD. After global hypothermic ischemia, significant decreases in stroke work, left ventricular contractility, and left ventricular relaxation were observed in the BD group compared with controls. Cardiac output and coronary flow were also significantly decreased in BD hearts compared with controls. Creatine kinase release was increased by 32.5% in BD hearts compared with controls. In a rabbit model, BD combined with global hypothermic ischemia causes a significant decrease in left ventricular function compared with global hypothermic ischemia. This dysfunction may be attributed to a significant decrease in coronary flows in BD hearts.

Citations

Sep 2, 1998·Transplantation Proceedings·M J WilhelmN L Tilney
May 20, 1999·Transplantation Proceedings·M KirschD Loisance
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M KirschD Loisance
May 16, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M J WilhelmN L Tilney
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P ChiariR Ferrera
Oct 25, 2006·Transplantation·Gérard AudibertPaul-Michel Mertes
Mar 17, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F FarhatM Kirsch
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Markus GollingArianeb Mehrabi
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Nicola E HiemannRudolf Meyer
Jan 30, 2002·Experimental Biology and Medicine·Jennifer M Smith, Charles F Pilati
Jan 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·T YehE R Jakoi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.