Brain-decoding fMRI reveals how wholes relate to the sum of parts

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Jonas KubiliusHans P Op de Beeck

Abstract

The human brain performs many nonlinear operations in order to extract relevant information from local inputs. How can we observe and quantify these effects within and across large patches of cortex? In this paper, we discuss the application of multi-voxel pattern analysis (MVPA) in functional magnetic resonance imaging (fMRI) to address this issue. Specifically, we show how MVPA (i) allows to compare various possibilities of part combinations into wholes, such as taking the mean, weighted mean, or the maximum of responses to the parts; (ii) can be used to quantify the parameters of these combinations; and (iii) can be applied in various experimental paradigms. Through these procedures, fMRI helps to obtain a computational understanding of how local information is integrated into larger wholes in various cortical regions.

References

Jan 1, 1992·Trends in Neurosciences·M A Goodale, A D Milner
Jan 1, 1987·Perception·A W YoungD C Hay
Jun 15, 1984·Science·R von der HeydtG Baumgartner
Oct 16, 2002·Nature Neuroscience·Chris I BakerCarl R Olson
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Jul 6, 2004·Nature Neuroscience·Scott L Brincat, Charles E Connor
Apr 27, 2005·Nature Neuroscience·Yukiyasu Kamitani, Frank Tong
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide ZoccolanJames J DiCarlo
Sep 28, 2006·Journal of Experimental Psychology. Human Perception and Performance·Collin Green, John E Hummel
Apr 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thomas SerreTomaso Poggio
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide ZoccolanJames J DiCarlo
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hans P Op de BeeckJohan Wagemans
Jan 17, 2009·Journal of Vision·Fang FangScott O Murray
May 19, 2009·Current Biology : CB·Sean P Macevoy, Russell A Epstein
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leila ReddyRufin VanRullen
Apr 27, 2010·Current Biology : CB·Yigal AgamGabriel Kreiman
Dec 15, 2010·Cerebral Cortex·Jiye G Kim, Irving Biederman
Jul 7, 2011·Journal of Experimental Psychology. Human Perception and Performance·James R Pomerantz, Mary C Portillo
Sep 6, 2011·Nature Neuroscience·Sean P MacEvoy, Russell A Epstein
Aug 1, 2012·Psychological Bulletin·Johan WagemansRüdiger von der Heydt
Dec 14, 2012·Nature Reviews. Cancer·Samy A F Morad, Myles C Cabot
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Holly BridgeAndrew J Parker
May 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Daniel L K YaminsJames J DiCarlo

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Citations

Oct 3, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Paolo BartolomeoMarlene Behrmann
Apr 14, 2016·Cerebral Cortex·Christopher BaldassanoLi Fei-Fei
Jan 25, 2018·Cerebral Cortex·Michael P NotterEveline Geiser
Jan 9, 2018·NeuroImage·Pranav G ReddyDanielle S Bassett

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