Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial.

EBioMedicine
Isabella C ArellanesHussein N Yassine

Abstract

Past clinical trials of docosahexaenoic Acid (DHA) supplements for the prevention of Alzheimer's disease (AD) dementia have used lower doses and have been largely negative. We hypothesized that larger doses of DHA are needed for adequate brain bioavailability and that APOE4 is associated with reduced delivery of DHA and eicosapentaenoic acid (EPA) to the brain before the onset of cognitive impairment. 33 individuals were provided with a vitamin B complex (1 mg vitamin B12, 100 mg of vitamin B6 and 800 mcg of folic acid per day) and randomized to 2,152 mg of DHA per day or placebo over 6 months. 26 individuals completed both lumbar punctures and MRIs, and 29 completed cognitive assessments at baseline and 6 months. The primary outcome was the change in CSF DHA. Secondary outcomes included changes in CSF EPA levels, MRI hippocampal volume and entorhinal thickness; exploratory outcomes were measures of cognition. A 28% increase in CSF DHA and 43% increase in CSF EPA were observed in the DHA treatment arm compared to placebo (mean difference for DHA (95% CI): 0.08 µg/mL (0.05, 0.10), p<0.0001; mean difference for EPA: 0.008 µg/mL (0.004, 0.011), p<0.0001). The increase in CSF EPA in non-APOE4 carriers after supplementation was thre...Continue Reading

Associated Clinical Trials

Sep 4, 2015·Hussein Yassine

Citations

Oct 20, 2020·Journal of Alzheimer's Disease : JAD·Tianying ZhangXingchun Gou
Mar 26, 2021·Frontiers in Nutrition·Maurizio Muscaritoli
Apr 4, 2021·International Journal of Molecular Sciences·Manon LeclercFrédéric Calon
Apr 30, 2021·Expert Review of Neurotherapeutics·Marjan TalebiSaeed Samarghandian
May 22, 2021·Biological Reviews of the Cambridge Philosophical Society·Matthias PileckyMartin J Kainz
May 30, 2021·BMC Bioinformatics·Chengyuan ShaTing Hu
Jun 1, 2021·Frontiers in Nutrition·Rita BusinaroPedro Zuzarte
May 20, 2021·Brain Communications·Gillian CoughlanAnne-Marie Minihane
Oct 29, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lin LiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Methods Mentioned

BETA
genotyping

Clinical Trials Mentioned

NCT02541929
NCT03613844

Software Mentioned

VITAL
ORIGIN
REDUCE
lipiDIDiet
Do
VITACOG
FreeSurfer
SAS
IT
R

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