Brain dendritic cells in ischemic stroke: time course, activation state, and origin.

Brain, Behavior, and Immunity
Jennifer C FelgerKaren Bulloch

Abstract

The immune response to stroke is comprised of inflammatory and regulatory processes. One cell type involved in both innate and adaptive immunity is the dendritic cell (DC). A DC population residing in the healthy brain (bDC) was identified using a transgenic mouse expressing enhanced yellow fluorescent protein (EYFP) under the promoter for the DC marker, CD11c (CD11c/EYFP Tg). To determine if bDC are involved in the immune response to cerebral ischemia, transient (40 min) middle cerebral artery occlusion (MCAO) followed by 6, 24, or 72 h reperfusion was conducted in CD11c/EYFP Tg mice. Our results demonstrated that DC accumulated in the ischemic hemisphere at 24 h post-MCAO-reperfusion, particularly in the border region of the infarct where T lymphocytes accrued. To distinguish resident bDC from the infiltrating peripheral DC, radiation chimeras [1. wild type (WT) hosts restored with CD11c/EYFP Tg bone marrow (BM) or 2. CD11c/EYFP Tg hosts restored with WT BM] were generated and examined by immunocytochemistry. These data confirmed that DC populating the core of the infarct at 72 h were of peripheral origin, whereas those in the border region were comprised primarily of resident bDC. The brain resident (CD45 intermediate) cells...Continue Reading

References

Oct 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C Adams
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A Swanson, F R Sharp
Dec 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K A BerghornG E Hoffman
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·T N LinC Y Hsu
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K J BeckerJ M Hallenbeck
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SantambrogioR Riese
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Nikolaos KostulasHans Link
Aug 6, 2002·Journal of Neuroimmunology·Gaby ReichmannHans-Georg Fischer
Oct 2, 2002·European Journal of Immunology·Claire N ManzottiDavid M Sansom
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Kennedy R LeesUNKNOWN UK-279,276-301 Study Investigators
Nov 16, 2004·Nature Immunology·Randall L LindquistMichel C Nussenzweig
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sunghee ChoCostantino Iadecola
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Halina OffnerPatricia D Hurn
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven M KerfootMark G Swain
Jan 25, 2006·Nature Medicine·Takayuki KawanoCostantino Iadecola
Apr 26, 2006·Circulation·Gokhan YilmazD Neil Granger
Dec 26, 2006·Journal of Neuroimmunology·Qing WangMidori A Yenari
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·J Michael GeeKyra J Becker
Jul 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander KunzCostantino Iadecola
Mar 1, 2008·Neuropharmacology·Kristian P DoyleMary P Stenzel-Poore
Sep 16, 2008·Neuroscience·B W McCollN J Rothwell
Feb 7, 2009·Nature Medicine·Anna M Planas, Angel Chamorro
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·Mathias GelderblomTim Magnus
Nov 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andres Gottfried-BlackmoreKaren Bulloch

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Citations

Jul 25, 2012·Acta Neuropathologica·Paul M D'AgostinoKaren Bulloch
Jul 25, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·B J L EggenH W G M Boddeke
Sep 6, 2013·Journal of Cardiovascular Translational Research·Rong JinGuohong Li
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Paul M D'AgostinoKaren Bulloch
Feb 5, 2010·Journal of Leukocyte Biology·Rong JinGuohong Li
May 31, 2014·BioMed Research International·Xiaomeng Xu, Yongjun Jiang
Nov 15, 2014·Experimental & Translational Stroke Medicine·Claudia PöselDaniel-Christoph Wagner
Nov 17, 2015·Biochimica Et Biophysica Acta·Peter LudewigAnna M Planas
Feb 3, 2016·Frontiers in Immunology·F Nina PapavasiliouKaren Bulloch
Oct 8, 2014·Journal of Neuroimmunology·Benjamin D ClarksonZsuzsanna Fabry
May 9, 2012·Hormones and Behavior·Rodney M RitzelLouise D McCullough
Feb 9, 2010·Brain, Behavior, and Immunity·Cobi J Heijnen, Annemieke Kavelaars
Jul 19, 2013·Journal of Neuropathology and Experimental Neurology·Xiangting ChenPaul G McMenamin
Sep 13, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tobias StubbeChristine Brandt
Dec 5, 2015·Frontiers in Cellular Neuroscience·Beatriz AlmoldaBernardo Castellano
Jul 19, 2015·Brain, Behavior, and Immunity·Erin GlennonKaren Bulloch
Oct 25, 2012·Journal of Neurochemistry·Kyra J Becker
Jul 24, 2010·British Journal of Pharmacology·Catherine E Downes, Peter J Crack
Aug 19, 2014·Glia·Peter WieghoferMarco Prinz
Mar 19, 2013·Journal of Neuroimmunology·Arthur LieszRoland Veltkamp
Sep 3, 2013·Experimental Neurology·Bharti ManwaniLouise D McCullough
Jan 1, 2012·Intravital·Debasis NayakDorian B McGavern
Aug 10, 2010·Neurobiology of Aging·Ulrike W KaunznerKaren Bulloch
Oct 14, 2014·Frontiers in Cellular Neuroscience·Xabier UrraAnna M Planas
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Francesc Miró-MurAnna M Planas
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Josef Anrather, Costantino Iadecola
Apr 17, 2018·International Journal of Molecular Sciences·Junaid AnsariFelicity N E Gavins
Nov 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Daniel C ColeKaren Bulloch
Jun 25, 2016·Circulation Research·Danica Petrovic-DjergovicDavid J Pinsky
Aug 28, 2020·Stress : the International Journal on the Biology of Stress·Firdaus S DhabharRobert L Spencer
Sep 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paulina Carmona-MoraBoryana Stamova

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