Brain-derived neurotrophic factor and collagen tubulization enhance functional recovery after peripheral nerve transection and repair

Archives of Otolaryngology--head & Neck Surgery
D S UtleyD J Terris

Abstract

To investigate the effect of brain-derived neurotrophic factor (BDNF) and collagen tubulization (CT) on the regeneration of transected peripheral nerves. METHODS AND DESIGNS: The left sciatic nerve of 40 Sprague-Dawley rats was transected then repaired using one of four techniques; epineurial coaptation, CT, CT with BDNF delivered by an osmotic pump to the repair site, or CT with BDNF covalently cross-linked to the collagen matrix (CT/linked-BDNF). Sciatic functional indices were measured preoperatively at 10-day intervals for 90 days. Segments of the sciatic nerves proximal and distal to the repair site were harvested at 90 days for histologic and morphometric evaluation. Animals repaired by CT/linked-BDNF (n=10) demonstrated the most favorable functional recovery of all groups, with statistically significant differences seen compared with animals repaired by CT (n=10, P=.05) and epineural coaptation (n=9, P<.001). Animals repaired by CT with BDNF delivered by an osmotic pump (n=8) and CT also showed statistically superior functional recovery compared with those repaired by epineurial coaptation (P=.005 and P=.02, respectively). Nerves repaired by CT/linked-BDNF had the largest mean axon diameters proximal and distal to the re...Continue Reading

Citations

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·H FunakoshiC F Ibáñez
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aikeremujiang MuheremuJiang Peng
May 5, 1999·Journal of Anatomy·G Terenghi
Jul 21, 2010·Journal of Neural Engineering·Edgar Y Walker, Dennis L Barbour
Dec 20, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas Madduri, Bruno Gander
Oct 19, 2010·Progress in Neurobiology·Ronald DeumensGary A Brook
Aug 12, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrew D H WilsonGiorgio Terenghi
May 8, 2007·Advanced Drug Delivery Reviews·Hyun Jung Chung, Tae Gwan Park
Feb 4, 2010·Journal of Neuroscience Research·Petrica-Adrian Panaite, Ibtissam Barakat-Walter
May 3, 2005·Neuroscience Letters·Toshihiko KadoyaHidenori Horie
Apr 10, 2004·Neurological Research·Jason S BelkasRajiv Midha
Dec 17, 2008·Neurological Research·Stephen W P KempRajiv Midha
Dec 3, 2014·Advanced Drug Delivery Reviews·Alessandro FaroniAdam J Reid
Apr 6, 2013·Journal of Korean Neurosurgical Society·Jin-Seok YiJi-Ho Yang
Oct 7, 2003·Annual Review of Biomedical Engineering·Christine E Schmidt, Jennie Baier Leach
Feb 8, 2003·Journal of Neuroscience Methods·D S McDonald, D W Zochodne
Jan 8, 1999·Microsurgery·S P FrostickG J Kemp
Sep 3, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·Q YinS P Frostick
Jun 18, 2002·Annals of Plastic Surgery·Adnan MenderesAli Barutçu
Sep 10, 2003·Journal of Neurosurgery·Rajiv MidhaMolly S Shoichet
Aug 24, 2018·Neural Regeneration Research·Jongbae ChoiSung Won Kwon
Feb 21, 2009·Neurosurgical Focus·Tessa Gordon
Jul 20, 2006·International Anesthesiology Clinics·Elizabeth Vernon PittsRita J Balice-Gordon
Sep 29, 2006·Journal of Anatomy·Paul J Kingham, Giorgio Terenghi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.