Brain-derived neurotrophic factor and substrate utilization following acute aerobic exercise in obese individuals

Journal of Neuroendocrinology
Aaron SlusherC-J Huang

Abstract

Brain-derived neurotrophic factor (BDNF) serves as a vital regulator of neuronal proliferation and survival, and has been shown to regulate energy homeostasis, glucose metabolism and body weight maintenance. Elevated concentrations of plasma BDNF have been associated with obesity and type 2 diabetes mellitus. Acute aerobic exercise transiently increases circulating BDNF, potentially correcting obesity-related metabolic impairment. The present study aimed to compare acute aerobic exercise elicited BDNF responses in obese and normal-weight subjects. Furthermore, we aimed to investigate whether acute exercise-induced plasma BDNF elevations would be associated with improved indices of insulin resistance, as well as substrate utilization [carbohydrate oxidation (CHOoxi) and fat oxidation (FAToxi)]. Twenty-two healthy, untrained subjects [11 obese (four men and seven women; age = 22.91 ± 4.44 years; body mass index = 35.72 ± 4.17 kg/m(2)) and 11 normal-weight (five men and six women; age = 23.27 ± 2.24 years; body mass index = 21.89 ± 1.63 kg/m(2))] performed 30 min of continuous submaximal aerobic exercise at 75% maximal oxygen consumption. Our analyses showed that the BDNF response to acute aerobic exercise was similar in obese and...Continue Reading

References

Mar 21, 1994·Brain Research·B Cheng, M P Mattson
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Feb 26, 2003·Metabolism: Clinical and Experimental·Akio KurodaMasatsugu Hori
Jun 28, 2003·Nature Neuroscience·Brent E Wisse, Michael W Schwartz
Nov 5, 2003·International Journal of Sports Medicine·J Achten, A E Jeukendrup
Sep 24, 2004·Psychosomatic Medicine·Palmiero MonteleoneMario Maj
Dec 9, 2004·Neurobiology of Aging·Marek LommatzschJohann Christian Virchow
Jul 22, 2005·International Journal of Clinical Practice·E CobanF Akcit
Apr 7, 2007·Medicine and Science in Sports and Exercise·Lee T FerrisChwan-Li Shen
May 19, 2007·The Journal of Clinical Investigation·Simon Schenk, Jeffrey F Horowitz
Apr 19, 2008·Neuroscience Letters·Yu NofujiShuzo Kumagai
Sep 10, 2008·Chronobiology International·Armando PiccinniLiliana Dell'Osso
Aug 12, 2009·Experimental Physiology·Peter RasmussenHenriette Pilegaard
Nov 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas SeifertNiels H Secher
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Gil Mor, Ingrid Cardenas
Jul 8, 2010·The International Journal of Neuropsychopharmacology·Anders B KleinSusana Aznar
Sep 9, 2011·Thrombosis and Haemostasis·Catherine P M Hayward
Jan 31, 2013·European Journal of Applied Physiology·Tore ChristiansenBjørn Richelsen
Oct 15, 2013·Cell Metabolism·Christiane D WrannBruce M Spiegelman
Oct 22, 2013·Physiology & Behavior·Chun-Jung HuangYoshimi Shibata
Nov 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Corey A RyndersArthur Weltman
Feb 28, 2014·Neuroscience Letters·Parvin BabaeiBahram Soltani Tehrani

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Citations

May 5, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley J Baranowski, Rebecca E K MacPherson
Mar 4, 2020·International Journal of Molecular Sciences·Avigdor D AradFred J DiMenna
Nov 2, 2019·The Journal of Sports Medicine and Physical Fitness·Viviane R ElsnerAlessandra Peres
Nov 21, 2018·Experimental Biology and Medicine·Alexandra L RodriguezChun-Jung Huang
Nov 28, 2018·BMC Sports Science, Medicine and Rehabilitation·Fred J DiMenna, Avigdor D Arad
Oct 31, 2019·Scientific Reports·Federica ScarpinaMarcello Costantini
Apr 22, 2021·Journal of Obesity & Metabolic Syndrome·Ravi Babu KaturiKarthik Shanmugavel

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