Brain-derived neurotrophic factor attracts geniculate ganglion neurites during embryonic targeting.

Developmental Neuroscience
Natalia HoshinoM William Rochlin

Abstract

Geniculate axons are initially guided to discrete epithelial placodes in the lingual and palatal epithelium that subsequently differentiate into taste buds. In vivo approaches show that brain-derived neurotrophic factor (BDNF) mRNA is concentrated in these placodes, that BDNF is necessary for targeting taste afferents to these placodes, and that BDNF misexpression disrupts guidance. We used an in vitro approach to determine whether BDNF may act directly on geniculate axons as a trophic factor and as an attractant, and whether there is a critical period for responsiveness to BDNF. We show that BDNF promotes neurite outgrowth from geniculate ganglion explants dissected from embryonic day (E) 15, E18, infant, and adult rats cultured in collagen gels, and that there is a concentration optimum for neurite extension. Gradients of BDNF derived from slow-release beads caused the greatest bias in neurite outgrowth at E15, when axons approach the immature gustatory papillae. Further, neurites advanced faster toward the BDNF bead than away from it, even if the average amount of neurotrophic factor encountered was the same. We also found that neurites that contact BDNF beads did not advance beyond them. At E18, when axons would be penetrat...Continue Reading

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Apr 10, 2012·Nature Neuroscience·Federico Dajas-BailadorNancy Papalopulu
Mar 31, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Benjamin KopeckyBernd Fritzsch
Jan 1, 2014·Developmental Biology·Tao Huang, Robin F Krimm
May 24, 2013·International Journal of Molecular Sciences·Francesco DifatoDan Cojoc
Jan 30, 2019·Neural Development·Jennifer Rios-Pilier, Robin F Krimm
Feb 26, 2016·Molecular Neurobiology·Sreekala S Nampoothiri, G K Rajanikant
Nov 10, 2014·Metabolic Brain Disease·Lingbin MengRui Ji

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