Brain-derived neurotrophic factor augments peristalsis by augmenting 5-HT and calcitonin gene-related peptide release

Gastroenterology
J R GriderLi Ya Qiao

Abstract

Brain-derived neurotrophic factor (BDNF) acts rapidly to modulate synaptic neurotransmission in the brain. Although present in neurons, glial cells, and mucosal cells of the colon, and in higher concentrations than in brain, the action of BDNF in gut have not been characterized. The aim of this study was to identify the role of BDNF in mediating the peristaltic reflex. BDNF and a specific antiserum were examined for their effects on the peristaltic reflex and release of the sensory mediators serotonin and calcitonin gene-related peptide in rat colon. The peristaltic reflex and release of serotonin and calcitonin gene-related peptide were also examined in genetically modified mice (BDNF(+/-)) with reduced levels of BDNF. Endogenous brain-derived neurotrophic factor was released into the sensory compartment in a stimulus-dependent manner during the peristaltic reflex induced by mucosal stimulation but not muscle stretch. BDNF stimulated and immunoneutralization of endogenous BDNF reduced ascending contraction and descending relaxation of circular muscle and release of serotonin and calcitonin gene-related peptide during the peristaltic reflex induced by mucosal stimulation but not muscle stretch. The peristaltic reflex and releas...Continue Reading

Citations

Nov 26, 2009·Therapeutic Advances in Gastroenterology·Alexandru GamanBraden Kuo
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Mar 25, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J R GriderK S Murthy
Sep 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·J R Grider, B E Piland
Dec 9, 2014·Frontiers in Biology·Li-Ya Qiao
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Al-QudahJ R Grider
Nov 5, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun SinghSatish Rattan
Nov 26, 2009·European Journal of Pain : EJP·Jing YangYanqing Li
Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Al-QudahJ R Grider
Nov 17, 2016·The Proceedings of the Nutrition Society·Mohamed-Sami TrabelsiXavier Collet
Sep 28, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sumei Liu
Apr 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kiyoshi TsukamotoToku Takahashi
Mar 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Renta KatsuiMiyako Takaki
Mar 16, 2018·Behavioural Pharmacology·Ana E López-PérezRaquel Abalo
May 13, 2015·Digestive Diseases and Sciences·Xiaojing QuanHong Xia
Feb 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arjun SinghSatish Rattan
Jun 3, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun Singh, Satish Rattan
Jun 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guannan YangXiaohong Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.