Brain-derived neurotrophic factor (BDNF) prevents lesion-induced axonal die-back in young rat optic nerve

Brain Research
D WeibelM E Schwab

Abstract

Lesions of the optic nerve in young animals lead to rapid retrograde degeneration of the axon stumps and to death of retinal ganglion cells. We injected different neurotrophic factors into the eye at the time of an intracranial freeze-crush lesion of the optic nerve in 8 day old rats. Optic nerve axons were visualized by anterograde tracing with wheat germ agglutinin-horseradish peroxidase (WGA-HRP) and by electron microscopy. The lesion induced a rapid die-back of the axons, which could be prevented by BDNF and to a lesser extent by neurotrophin-3 (NT-3) or ciliary neurotrophic factor (CNTF). No effect was seen in animals injected with nerve growth factor (NGF) or a mixture of acidic and basic fibroblast growth factor (FGF). In contrast to this effect on the axons, none of these factors was able to counteract the rapidly progressing degeneration of the retinal ganglion cells. These results suggest a selective influence of BDNF on the mechanisms responsible for the maintenance of optic nerve axons.

References

Feb 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M Mesulam
Nov 1, 1992·Journal of Neurobiology·W D SniderQ Yan
Jun 1, 1989·Neuron·Y A Barde
Dec 1, 1982·Journal of Neurocytology·P M RichardsonS Shemie
Apr 1, 1994·Neuron·S Cohen-Cory, S E Fraser
Sep 1, 1993·The European Journal of Neuroscience·L Schnell, M E Schwab
Jan 1, 1989·The European Journal of Neuroscience·Solon ThanosJens Vanselow
Oct 1, 1992·The European Journal of Neuroscience·Patrik ErnforsHåkan Persson

❮ Previous
Next ❯

Citations

Jun 9, 2000·Annual Review of Neuroscience·J L Goldberg, B A Barres
Jul 9, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Takashi OtaNobuaki Miyawaki
Nov 4, 2017·Cellular and Molecular Life Sciences : CMLS·Martina GiannacciniVittoria Raffa
Feb 10, 1999·The Journal of Comparative Neurology·E CaminosE Vecino
Mar 7, 2012·Cell and Tissue Research·Paul LingorMathias Bähr
Oct 17, 1998·Eye·P J Luthert, N H Chong
Dec 7, 2019·Current Opinion in Neurology·Kimberly K GokoffskiPhillip Lam
Feb 26, 2003·Annals of Neurology·Martin KerschensteinerReinhard Hohlfeld
May 1, 2016·Fundamental & Clinical Pharmacology·Fatemeh MohammadiShahram Ejtemaei Mehr
Mar 22, 2019·Investigative Ophthalmology & Visual Science·Ting ShenYuyi You
Aug 5, 2000·Progress in Retinal and Eye Research·P Heiduschka, S Thanos
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Apr 15, 2004·Molecular and Cellular Neurosciences·Gabriela Chytrova, James E Johnson
Sep 12, 2006·Progress in Retinal and Eye Research·Alan R HarveyQi Cui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.