Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats.

Neuroscience Letters
Clifton W CallawayMelissa J Repine

Abstract

Increased brain-derived neurotrophic factor (BDNF) levels and extracellular-signal regulated kinase (ERK) signaling are associated with reduced brain injury after cerebral ischemia. In particular, mild hypothermia after cardiac arrest increases BDNF and ERK signaling. This study tested whether intracerebroventricular infusions (0.025 microg/h x 3 days) of BDNF also improved recovery of rats resuscitated from cardiac arrest and maintained at 37 degrees C. BDNF infusions initiated at the time of cardiac arrest did not alter survival, neurological recovery, or histological injury. Separate experiments confirmed that BDNF infusions increased tissue levels of BDNF. However, these infusions did not increase ERK activation in hippocampus. These data suggest that increased BDNF levels are not sufficient to explain the beneficial effects of mild hypothermia after cardiac arrest, and that exogenous BDNF administration does not increase extracellular ERK signaling.

References

Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BeckA Wree
Oct 31, 1998·Brain Research. Molecular Brain Research·H S OliffC W Cotman
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E LarssonO Lindvall
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brian J D'CruzClifton W Callaway
Jul 31, 2002·Circulation·Christophe AdrieJean-Marc Cavaillon

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Citations

Feb 15, 2014·Clinics in Perinatology·Paul P DruryAlistair J Gunn
Apr 4, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert M DietzPaco S Herson

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