Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C

American Journal of Physiology. Gastrointestinal and Liver Physiology
M Al-QudahJ R Grider

Abstract

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of proteins best known for its role in neuronal survival, differentiation, migration, and synaptic plasticity in central and peripheral neurons. BDNF is also widely expressed in nonneuronal tissues including the gastrointestinal tract. The role of BDNF in intestinal smooth muscle contractility is not well defined. The aim of this study was to identify the role of BDNF in carbachol (CCh)- and substance P (SP)-induced contraction of intestinal longitudinal smooth muscle. BDNF, selective tropomyosin-related kinase B (TrkB) receptor agonists, and pharmacological inhibitors of signaling pathways were examined for their effects on contraction of rabbit intestinal longitudinal muscle strips induced by CCh and SP. BDNF activation of intracellular signaling pathways was examined by Western blot in homogenates of muscle strips and isolated muscle cells. One-hour preincubation with BDNF enhanced intestinal muscle contraction induced by CCh but not by SP. The selective synthetic TrkB agonists LM 22A4 and 7,8-dihydroxyflavone produced similar effects to BDNF. The Trk antagonist K-252a, a TrkB antibody but not p75NTR antibody, blocked the effect of BDNF. The enhancem...Continue Reading

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Citations

Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Al-QudahJ R Grider
May 13, 2015·Digestive Diseases and Sciences·Xiaojing QuanHong Xia
Aug 19, 2014·Journal of Neural Transmission·Chiara FabbriAlessandro Serretti
Apr 20, 2014·American Journal of Hypertension·Frans H H Leenen
Jul 18, 2019·Clinical and Experimental Pharmacology & Physiology·Li MaBaoguo He
Nov 5, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun SinghSatish Rattan
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Marco EmiliFiorenza Stagni
Aug 30, 2014·Journal of Applied Physiology·Carlos B MantillaGary C Sieck
Mar 16, 2018·Behavioural Pharmacology·Ana E López-PérezRaquel Abalo
Sep 28, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sumei Liu
Feb 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arjun SinghSatish Rattan
Jun 3, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun Singh, Satish Rattan

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