Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease

Journal of Neural Transmission
S MatsushitaS Higuchi

Abstract

Several lines of evidence have made brain-derived neurotrophic factor (BDNF) an important candidate gene conferring risk for Alzheimer's disease (AD). Recently, three studies reported an association between two single-nucleotide polymorphisms (SNP)--i.e., C270T and G196A--in the BDNF gene and AD. This attempt to confirm these associations in a larger AD sample included examination of the linkage disequilibrium of these two SNPs. Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046). These findings suggest that BDNF gene polymorphisms play some role in the development of AD.

Citations

Feb 8, 2008·Genes, Brain, and Behavior·K SchindowskiL Buée
Feb 13, 2007·Journal of Medical Genetics·R HuangS E Poduslo
Jul 8, 2008·Journal of Psychiatric Research·Edna GrünblattPeter Fischer
Nov 26, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sang Jun LeeYoung-Hoon Kim
May 15, 2007·Brain Research Bulletin·Viktorija TrajkovskaGitte M Knudsen
Oct 29, 2008·Headache·Helen E Scharfman, Neil J MacLusky
Oct 18, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaohui XuPhilip Asherson
Sep 29, 2011·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Tomoyuki NagataHisashi Yamada
Aug 18, 2012·International Journal of Geriatric Psychiatry·Maria Aparecida Camargos BicalhoLuiz De Marco
Jun 9, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Noriko FukumotoHiroshi Kunugi
Aug 2, 2011·Neurobiology of Aging·Patrick D GajewskiChristian Beste
Apr 19, 2011·NeuroImage·Derrek P HibarUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 19, 2015·Cognitive, Affective & Behavioral Neuroscience·Ana KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 20, 2011·Brain Research Bulletin·Chen-Jee HongShih-Jen Tsai
Nov 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nela PivacDorotea Muck Seler
Nov 12, 2014·Frontiers in Neurology·Fabiola De MarchiCristoforo Comi
May 27, 2016·Expert Review of Neurotherapeutics·Amene SaghazadehNima Rezaei
Jun 6, 2009·Nature Reviews. Neurology·Chiara Zuccato, Elena Cattaneo
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Agnes FehérZoltán Janka
Dec 8, 2006·Diabetologia·K S KrabbeB K Pedersen

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