Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei

Brain Research
H IchikawaTomosada Sugimoto

Abstract

Immunohistochemistry for brain-derived neurotrophic factor (BDNF) was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 46% of TG neurons. These neurons were mostly small- or medium-sized (range, 149.7-1246.3 microm2; mean +/- SD = 373.4 +/- 151.6 microm2). A double immunofluorescence method also revealed that 54% of BDNF-immunoreactive (IR) neurons were immunoreactive for calcitonin-gene-related peptide. In addition, 93% of BDNF-IR TG neurons contained vanilloid receptor subtype 1. However, the co-expression of BDNF and vanilloid receptor 1-like receptor was very rare (less than 1%). In the trigeminal sensory nuclei, laminae II of the medullary dorsal horn was abundant in presumed BDNF-IR axon terminals. Such profiles were also detected in the dorsolateral part of the subnucleus oralis. The retrograde tracing and immunohistochemical methods demonstrated that BDNF-IR was common among cutaneous TG neurons (47%) but not tooth pulp TG neurons (13%). The present study indicates that BDNF-IR TG neurons have unmyelinated axons and project to the superficial medullary dorsal horn. It is likely that BDNF-containing neurons in both the trigeminal and spinal sensory systems have similarities in morp...Continue Reading

References

Mar 15, 1989·Experientia·H IchikawaM Akai
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W ThompsonS B McMahon
Feb 13, 2001·Brain Research·H Ichikawa, T Sugimoto
Apr 11, 2001·Brain Research. Molecular Brain Research·H IchikawaT Sugimoto
Nov 19, 2003·The European Journal of Neuroscience·Sandra M GarrawayLorne M Mendell
Feb 22, 2005·Neuroscience Letters·Tatiana González-MartínezJosé A Vega

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Citations

Nov 16, 2013·Current Pain and Headache Reports·Nada Ahmad HindiyehRobert Paul Cowan
May 16, 2012·The Journal of Headache and Pain·Marlene FischerGregor Broessner
Feb 15, 2011·Journal of Biomedical Materials Research. Part a·Jose Miguel SoriaCarmen Carda
Nov 26, 2009·Menopause : the Journal of the North American Menopause Society·Alessandra CubedduAndrea R Genazzani
May 19, 2021·Neurological Research·Vasiliki KouteEfthimios Dardiotis

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