Brain-derived neurotrophic factor in primary headaches.

The Journal of Headache and Pain
Marlene FischerGregor Broessner

Abstract

Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide. Bi-center prospective study was done enrolling four diagnostic groups: episodic migraine with and without aura, episodic cluster headache, frequent episodic tension-type headache, and healthy individuals. In migraineurs, venous blood samples were collected twice: outside and during migraine attacks prior to pain medication. In cluster headache patients serum samples were collected in and outside cluster bout. Analysis of BDNF was performed using enzyme-linked immunosorbent assay technique. Migraine patients revealed significantly higher BDNF serum levels during migraine attacks (n = 25) compared with headache-free intervals (n = 53, P < 0.01), patients with tension-type headache (n = 6, P < 0.05), and healthy controls (n = 22, P < 0.001). There was no significant difference between patients with migraine with aura compared with those without aura, neither during migraine attacks nor during headache-free periods. Cluster headache patients showed significantly higher BDNF...Continue Reading

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Citations

Nov 16, 2013·Current Pain and Headache Reports·Nada Ahmad HindiyehRobert Paul Cowan
Feb 26, 2014·International Journal of Molecular Sciences·Dong LinChuanhai Cao
Oct 5, 2013·Headache·Cynthia L MayerElaine Peskind
Apr 9, 2014·Headache·Heidi G SutherlandLyn R Griffiths
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Jul 10, 2021·Frontiers in Neuroscience·Charlotte K BainomugisaDivya Mehta

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
contraception

Software Mentioned

GraphPad Prism
SPSS
PASW

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