PMID: 9185679May 23, 1997Paper

Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells

Neuroscience Letters
E T CoffeyM J Courtney

Abstract

We have examined the effects of neurotrophins brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) on the expression of the maturation-specific proteins synaptophysin and tau, and the growth-associated protein (GAP)-43 in cerebellar granule cells. We find that BDNF but not NGF rapidly (within 2 h) upregulates levels of synaptophysin, tau and c-Fos correlating with expression of the neurotrophin receptor TrkB. The rapid increase in synaptophysin is not preceded by c-Fos elevation suggesting a post-transcriptional mechanism may be involved. In contrast, no upregulation of GAP-43 levels are seen within this time period. Phorbol ester mimics the effects of BDNF, indicating that protein kinase C (PKC) is either a component of, or feeds into the signalling mechanism. We conclude that BDNF, characterized to be survival promoting early in differentiation of cerebellar granule cells, enhances maturation at a later stage.

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Citations

Sep 23, 2006·Molecular and Cellular Biochemistry·Osamu YokoyamaHidetoshi Ishibashi
May 10, 2000·Neuroscience Research·T NumakawaH Hatanaka
Apr 14, 2000·Brain Research. Molecular Brain Research·D FrechillaJ Del Río
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Feb 10, 2016·Alzheimer's Research & Therapy·Eun Ji LeeSangYun Kim
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Mar 5, 2011·Neurobiology of Aging·Veronica LifshitzDan Frenkel
Aug 24, 2005·International Journal of Geriatric Psychiatry·C G BallardE K Perry
Sep 18, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Joanna SikoraMagdalena Markowicz-Piasecka
Jan 19, 2019·Annals of Clinical and Translational Neurology·Chris McKinnonSuneil K Kalia
Apr 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jie XiangKeqiang Ye
Sep 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Trinh NguyenMeharvan Singh
Dec 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jerome A J BeckerJulie Le Merrer

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