Brain-derived neurotrophic factor inhibits calcium channel activation, exocytosis, and endocytosis at a central nerve terminal

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Maryna BaydyukLing-Gang Wu

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic function and plasticity and plays important roles in neuronal development, survival, and brain disorders. Despite such diverse and important roles, how BDNF, or more generally speaking, neurotrophins affect synapses, particularly nerve terminals, remains unclear. By measuring calcium currents and membrane capacitance during depolarization at a large mammalian central nerve terminal, the rat calyx of Held, we report for the first time that BDNF slows down calcium channel activation, including P/Q-type channels, and inhibits exocytosis induced by brief depolarization or single action potentials, inhibits slow and rapid endocytosis, and inhibits vesicle mobilization to the readily releasable pool. These presynaptic mechanisms may contribute to the important roles of BDNF in regulating synapses and neuronal circuits and suggest that regulation of presynaptic calcium channels, exocytosis, and endocytosis are potential mechanisms by which neurotrophins achieve diverse neuronal functions.

Citations

Mar 15, 2016·Frontiers in Synaptic Neuroscience·Christoph Körber, Thomas Kuner
Sep 17, 2015·Journal of Neurochemistry·Luis B Tovar-Y-RomoJosué O Ramírez-Jarquín
Mar 26, 2016·Frontiers in Cellular Neuroscience·Joachim Scholz-Starke, Fabrizia Cesca
Mar 29, 2016·Hearing Research·Maryna BaydyukLing-Gang Wu
Apr 1, 2017·Cellular and Molecular Life Sciences : CMLS·Ya-Long Wang, Claire Xi Zhang
Jun 18, 2019·The International Journal of Neuroscience·Jackson SarafPallab Bhattacharya
Jan 4, 2020·Translational Stroke Research·Kou-Jen WuSeong-Jin Yu
Nov 27, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joshua L Plotkin, Chengbiao Wu
Oct 1, 2020·International Journal of Molecular Sciences·Mikhail V VoroninSergei B Seredenin
Feb 11, 2021·Chemical Research in Toxicology·Bonnie RobinsonJyotshna Kanungo
Oct 6, 2021·Nature Communications·Rasheen PowellArin Bhattacharjee

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