Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus

E CastrénD Lindholm


We have detected scattered brain-derived neurotrophic factor mRNA-producing neurons in the medial septal nucleus, which contains cholinergic neurons that are responsive to brain-derived neurotrophic factor and nerve growth factor. In the brainstem, many adrenergic neurons showed a positive signal for brain-derived neurotrophic factor messenger RNA. Several hypothalamic nuclei contain brain-derived neurotrophic factor messenger RNA-positive neurons, among them paraventricular, median preoptic, vetromedial and dorsomedial nuclei. Osmotic stimulus, which activates vasopressin-producing neurons increased brain-derived neurotrophic factor messenger RNA levels in the paraventricular nucleus demonstrating that this factor is regulated by neuronal activity not only in the hippocampus and cortex but also in the hypothalamus.


Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E CastrénD Lindholm
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B KnüselF Hefti
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P ErnforsH Persson
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K R Jones, L F Reichardt
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Apr 14, 1986·Biochemical and Biophysical Research Communications·S FurukawaK Hayashi
Jun 1, 1989·Neuron·Y A Barde
Jul 1, 1991·The European Journal of Neuroscience·W J FriedmanHåkan Persson


Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Jun 9, 2006·Bulletin of Experimental Biology and Medicine·D S MelkumyanS B Seredenin
May 1, 1996·Pharmacology, Biochemistry, and Behavior·Enrico AllevaL Aloe
Mar 12, 2002·The European Journal of Neuroscience·Sari LähteinenE Castrén
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Freddy D JeanneteauMoses V Chao
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A SmithR M Post
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Mar 16, 2000·The EMBO Journal·S G KernieL F Parada
May 28, 1998·Neuroreport·F MarmigereSandor Arancibia
Feb 25, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emily E NobleChuanFeng Wang
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M CanossaH Thoenen
Dec 18, 2001·Journal of Neuroscience Research·F MarmigèreLucia Tapia-Arancibia
Dec 20, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Badowska-Szalewska EwaMoryś Janusz
Oct 24, 2009·Neuroscience Letters·Soo-Young BhangJoon-Ho Ahn
May 16, 2009·Frontiers in Neuroendocrinology·Francesca Cirulli, Enrico Alleva
Aug 19, 2008·Brain Research Reviews·Lucia Tapia-ArancibiaSandor Arancibia
Sep 4, 2007·Brain Research Reviews·C D FowlerZuoxin Wang
Apr 10, 2007·Biochemical Pharmacology·K S Rommelfanger, David Weinshenker
Jul 6, 2004·The European Journal of Neuroscience·Anna S CroninFrancis J P Ebling
Feb 18, 2010·Journal of Cellular and Molecular Medicine·Per NilssonTakaomi C Saido
Aug 29, 2013·The Journal of Comparative Neurology·Livia D'AngeloAlessandro Cellerino
Nov 3, 2004·Molecular and Cellular Neurosciences·Laurent GivaloisLucia Tapia-Arancibia
Jun 16, 2015·Oxidative Medicine and Cellular Longevity·Maria V VedunovaIrina V Mukhina
Jun 26, 2013·European Journal of Pharmacology·Anjana BaliAmteshwar Singh Jaggi
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong-Tian ZhangTim Ting-Hua Wang
Nov 11, 2017·The Journal of Comparative Neurology·Pietro CacialliCarla Lucini
Sep 8, 2018·ELife·Kristen R MaynardKeri Martinowich
Jan 13, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Benedek ErdosDeborah A Scheuer
Sep 19, 2020·Nature Reviews. Neuroscience·Gina R PoeSusan J Sara
Aug 13, 2020·Biomolecules·Claudia Jorgensen, Zuoxin Wang
Oct 17, 2018·International Journal of Molecular Sciences·Carla LuciniPaolo de Girolamo
Sep 28, 2018·Frontiers in Neuroscience·Laura M ButkovichMalú G Tansey
Oct 12, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Daniella ThorsdottirBenedek Erdos
Mar 25, 2018·Neurotoxicity Research·Meng-Yang Zhu
Jan 13, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hyo In KimHyun Jin Choi

Related Concepts

Adrenergic Fibers
Brain Stem
Nucleus Globosus
Insula of Reil
Organum Vasculosum Laminae Terminalis
Neurite Outgrowth Factors
Nerve Tissue Proteins
Osmotic Stress
Structure of Paraventricular Nucleus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.