Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

Neuroscience
Albert GiraltJordi Alberch

Abstract

The involvement of brain-derived neurotrophic factor (BDNF) in cognitive processes and the decrease in its expression in Huntington's disease suggest that this neurotrophin may play a role in learning impairment during the disease progression. We therefore analyzed the onset and severity of cognitive deficits in two different mouse models with the same mutant huntingtin but with different levels of BDNF (R6/1 and R6/1:BDNF+/- mice). We observed that BDNF modulates cognitive function in different learning tasks, even before the onset of motor symptoms. R6/1:BDNF+/- mice showed earlier and more accentuated cognitive impairment than R6/1 mice at 5 weeks of age in discrimination learning; at 5 weeks of age in procedural learning; and at 9 weeks of age in alternation learning. At the earliest age at which cognitive impairment was detected, electrophysiological analysis was performed in the hippocampus. All mutant genotypes showed reduced hippocampal long term potentiation (LTP) with respect to wild type but did not show differences between them. Thus, we evaluated the involvement of BDNF-trkB signaling and glutamate receptor expression in the hippocampus of these mice. We observed a decrease in phospholipaseCgamma activity, but not ...Continue Reading

References

May 1, 1987·Pharmacology, Biochemistry, and Behavior·M Upchurch, J M Wehner
Oct 1, 1996·Brain : a Journal of Neurology·A D LawrenceT W Robbins
Feb 10, 1997·Neuroreport·A Montkowski, F Holsboer
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Jul 29, 1998·Brain : a Journal of Neurology·A D LawrenceB J Sahakian
Dec 2, 2000·Behavioural Brain Research·P Chapillon, A Debouzie
Oct 24, 2001·Trends in Neurosciences·C Lüscher, M Frerking
May 14, 2003·Behavioural Brain Research·Hennariikka IivonenJukka Puoliväli
Jun 5, 2003·Journal of Neurophysiology·Eduardo D Martín, Washington Buño
Dec 9, 2003·Behavioural Brain Research·Ayhan SikArjan Blokland
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary C BaquetKevin R Jones
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy M Van RaamsdonkMichael R Hayden
Jun 2, 2005·Nature Reviews. Neuroscience·Mary B KennedyLorraine R Washburn
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Sep 30, 2005·Behavioural Brain Research·Douglas WahlstenJohn C Crabbe
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Derya R ShimshekRolf Sprengel

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Citations

Dec 31, 2010·Molecular Neurobiology·Bernardo Moreno-LópezDavid González-Forero
Sep 5, 2012·Molecular Neurobiology·Pawel M SwitonskiMaciej Figiel
Sep 18, 2013·Advances in Biological Regulation·Yong Ryoul YangPann-Ghill Suh
Jan 31, 2012·Neurology Research International·Tatyana VagnerAlexandre Mouravlev
Nov 2, 2011·Molecular Neurodegeneration·Xavier XifróJordi Alberch
May 24, 2011·PloS One·Susanna PietropaoloYoon H Cho
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuxiang XieBaoji Xu
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana SaavedraEsther Pérez-Navarro
Feb 18, 2010·International Journal of Molecular Sciences·Sheng PengBingxu Ren
Sep 3, 2014·The Journal of Clinical Investigation·Verónica BritoSílvia Ginés
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Danielle A SimmonsFrank M Longo
Aug 13, 2011·Human Molecular Genetics·Albert GiraltEsther Pérez-Navarro
Jan 26, 2013·Pharmacology & Therapeutics·Shelley J AllenNikunj K Patel
Nov 22, 2011·Behavioural Brain Research·Dagmar H ZeefYasin Temel
Oct 16, 2015·Human Molecular Genetics·Mar PuigdellívolSilvia Ginés
Dec 8, 2015·Advances in Biological Regulation·Yong Ryoul YangPann-Ghill Suh
Jan 15, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kari PollockJan A Nolta
Feb 16, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·László Bodai, J Lawrence Marsh
Jun 23, 2011·The European Journal of Neuroscience·Xuan Li, Marina E Wolf
Jul 29, 2010·Journal of Neurochemistry·Daniel del ToroJordi Alberch
Aug 2, 2012·Neural Plasticity·Rinske VlamingsYasin Temel
Dec 3, 2014·Neurobiology of Disease·Shiraz TyebjiEsther Pérez-Navarro
May 16, 2014·Neurobiology of Disease·Christina MoAnthony J Hannan
Oct 16, 2012·Advances in Biological Regulation·Hyun-Jun JangPann-Ghill Suh
Dec 3, 2014·Behavioural Brain Research·Xuan Li, Marina E Wolf
Apr 17, 2015·Molecular Neurobiology·Núria Martín-FloresCristina Malagelada
Jul 28, 2016·Addiction Biology·Cristina Lao-PeregrínEduardo D Martín
Aug 17, 2016·Brain Pathology·Mar PuigdellívolEsther Pérez-Navarro
Feb 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zahra DargaeiMelanie A Woodin

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