Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats

Medicine and Science in Sports and Exercise
M PedardC Marie

Abstract

The elevation of brain-derived neurotrophic factor (BDNF) levels in the brain and the subsequent phosphorylation of its cognate tropomyosin-related kinase B (TrkB) receptors at tyrosine 816 (pTrkB) are largely involved in the positive effect of aerobic exercise on brain functioning. Although BDNF levels were reported to increase in proportion with exercise intensity, the effect of the type of contraction is unknown. Therefore, the cerebral BDNF/TrkB pathway was investigated after uphill and downhill treadmill activities at equivalent intensity to preferentially induce eccentric and concentric contractions, respectively. A treadmill activity (30 min·d for seven consecutive days) either in a horizontal position at two different speeds to modulate intensity (experiment 1) or at three different inclinations (null, -10%, and +5%) but at equivalent intensity to modulate the type of contraction (experiment 2) was induced in rats. Both experiments included sedentary rats. Levels of BDNF, pTrkB, synaptophysin (marker of synaptogenesis), endothelial nitric oxide synthase phosphorylated at serine 1177 (peNOS), and c-fos levels (indicators of elevation in blood flow in the cerebrovasculature and neuronal activity, respectively) were measur...Continue Reading

References

Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E R de KloetW Sutanto
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·L L SmithK F O'Brien
Jan 1, 1971·Brain : a Journal of Neurology·J Olesen
Jan 12, 1995·Nature·S A NeeperC Cotman
Dec 5, 1998·Neurochemistry International·K J Kovács
Feb 13, 1999·The European Journal of Neuroscience·A CzurkóG Buzsáki
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla
Dec 21, 2005·Neuroscience Research·Takeshi Nishijima, Hideaki Soya
Aug 29, 2007·Sports Medicine·Jordan S Querido, A William Sheel
Dec 3, 2008·The European Journal of Neuroscience·Fernando Gomez-PinillaZhe Ying
Mar 12, 2010·Neuroscience·N C BerchtoldC W Cotman
May 10, 2013·Sports Medicine·Marie-Eve Isner-HorobetiRuddy Richard
Jul 5, 2013·Journal of Applied Physiology·Paul LaStayoStan Lindstedt
Oct 15, 2013·Cell Metabolism·Christiane D WrannBruce M Spiegelman
Jul 24, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hayat BanoujaafarChristine Marie
Apr 11, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Farzam SheikhzadehPeyman Zare
Dec 10, 2015·Cellular and Molecular Life Sciences : CMLS·Ricardo C CassilhasMarco Túlio de Mello
Mar 19, 2016·Frontiers in Neuroendocrinology·Juan Triviño-ParedesBrian R Christie
Jun 17, 2016·The European Journal of Neuroscience·Hayat BanoujaafarChristine Marie
Oct 28, 2016·Behavioural Brain Research·Yoann M GarnierChristos Paizis
Oct 31, 2017·European Journal of Sport Science·Stéphane Perrey
Mar 25, 2018·Neuroscience and Biobehavioral Reviews·Nikolas J StimpsonAmir-Homayoun Javadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.