PMID: 8584263Nov 10, 1995Paper

Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion

Neuroscience Letters
L NovikovJ O Kellerth

Abstract

In adult spinal motoneurons, retrograde cell death is induced by ventral root avulsion. A lethal effect of nitric oxide has been implicated, since nitric oxide synthase (NOS) is expressed in the motoneurons destined to die. Our study investigates the effects of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) on the retrograde cell death and NOS expression of adult rat spinal motoneurons. Following ventral root avulsion and 4 weeks of continuous treatment, BDNF, but not CNTF, was found to prevent cell death and NOS expression in the lesioned motoneurons. This suggests a therapeutic potential for BDNF in the adult nervous system, possibly through blockage of nitric oxide synthesis.

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 16, 1994·Brain Research. Developmental Brain Research·L GreensmithG Vrbová
Feb 24, 1994·Neuroreport·F PiehlS Cullheim
Apr 1, 1994·The Journal of Comparative Neurology·V E KoliatsosD L Price
Feb 1, 1993·Current Opinion in Neurobiology·S Davis, G D Yancopoulos
Apr 1, 1993·Current Opinion in Cell Biology·S Davis, G D Yancopoulos
Apr 30, 1993·Brain Research·M MataD J Fink

❮ Previous
Next ❯

Citations

Nov 15, 2000·The Journal of Comparative Neurology·L N NovikovaJ O Kellerth
Dec 6, 2005·Experimental Brain Research·Marcus OhlssonLeif A Havton
May 15, 2008·Experimental Brain Research·Thao X HoangLeif A Havton
May 30, 1998·Brain Research·D E Oorschot, I S McLennan
Sep 13, 2003·European Journal of Pharmacology·Rebecka JohanssonKatarina Persson
Apr 15, 1999·Journal of the Neurological Sciences·Y K SohnS M de la Monte
Aug 1, 1997·Neurochemistry International·E C KaalP R Bär
May 5, 1999·Journal of Anatomy·G Terenghi
Jun 4, 2010·Cold Spring Harbor Perspectives in Biology·Roman J GigerMark H Tuszynski
Dec 31, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kazuhiko WatabeYoko Kawazoe
Mar 28, 1998·The European Journal of Neuroscience·L NovikovaJ O Kellerth
Jan 26, 2007·Acta Physiologica·G Lundborg, B Rosén
Apr 22, 2003·Archives of Histology and Cytology·Jian-Wen HeMasaru Kawabuchi
Dec 17, 2008·Neurological Research·Andrew M HartMikael Wiberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.