Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice

The European Journal of Neuroscience
Sari LähteinenEero Castrén

Abstract

Brain-derived neurotrophic factor (BDNF) regulates neuronal survival, differentiation and plasticity. It has been shown to promote epileptogenesis and transgenic mice with decreased and increased BDNF signaling show opposite alterations in epileptogenesis. However, the mechanisms of BDNF action are largely unknown. We studied the gene expression changes 12 days after kainic acid-induced status epilepticus in transgenic mice overexpressing either the functional BDNF receptor trkB or a dominant-negative truncated trkB. Epileptogenesis produced marked changes in expression of 27 of 1090 genes. Cluster analysis revealed BDNF signalling-mediated regulation of functional gene classes involved in cellular transport, DNA repair and cell death, including kinesin motor kinesin family member 3A involved in cellular transport. Furthermore, the expression of cytoskeletal and extracellular matrix components, such as tissue inhibitor of metalloproteinase 2 was altered, emphasizing the importance of intracellular transport and interplay between neurons and glia during epileptogenesis. Finally, mice overexpressing the dominant-negative trkB, which were previously shown to have reduced epileptogenesis, showed a decrease in mRNAs of several growt...Continue Reading

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Citations

Dec 6, 2005·Experimental Brain Research·Andréanne BédardAndré Parent
Sep 8, 2005·Epilepsy Currents·Helen E Scharfman
Jul 1, 2005·BMC Bioinformatics·Petri PehkonenPetri Törönen
Mar 15, 2016·Frontiers in Neuroscience·José R Pineda, Juan M Encinas
Aug 1, 2006·Epilepsy Research·Zuzanna Setkowicz, Agnieszka Mazur
Apr 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Eleonora Aronica, Jan A Gorter
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Cara J WestmarkJames S Malter

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