PMID: 9427524Jan 14, 1998Paper

Brain-derived neurotrophic factor stimulates phosphorylation of stathmin in cortical neurons

Brain Research. Molecular Brain Research
J R CardinauxJ L Martin

Abstract

We have identified by two-dimensional polyacrylamide gel electrophoresis a protein known as stathmin which is phosphorylated in a time- and concentration-dependent manner in response to brain-derived neurotrophic factor (BDNF) in primary cultures of cortical neurons. We show that stathmin phosphorylation is preceded by the activation of mitogen-activated protein kinase (MAPK) isoforms p44 and p42. Moreover, the MAPK kinase inhibitor PD 098059, which inhibits MAPK activation, also markedly reduces BDNF-stimulated phosphorylation of stathmin, therefore suggesting that phosphorylation of stathmin is triggered by the activation of MAPK. Phosphorylation of stathmin is specific for BDNF since nerve growth factor does not stimulate MAPK and stathmin phosphorylation in cultured cortical neurons. Taken together, these results identify stathmin as a new target protein of BDNF, possibly involved in the development of cortical neurons.

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Citations

Jan 3, 2001·Journal of Cellular Biochemistry·B AntonssonG Grenningloh
Jul 16, 2010·The Journal of Biological Chemistry·Dominic C H NgMarie A Bogoyevitch
Feb 3, 1999·Annals of the New York Academy of Sciences·P J MagistrettiJ L Martin
Aug 27, 2013·PloS One·Michael RoheThomas E Willnow
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Krisztián A KovácsJean-René Cardinaux
Apr 12, 2007·Hippocampus·Wei-Fei DiaoGert Lubec
Jun 15, 2006·Journal of Neurochemistry·Krisztián A KovácsJean-René Cardinaux
Jul 28, 2015·Neurobiology of Learning and Memory·Shusaku Uchida, Gleb P Shumyatsky
Jan 18, 2015·Anatomical Science International·Masaya TohyamaShinsuke Matsuzaki
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kunlin JinDavid A Greenberg
Nov 23, 2017·Scientific Reports·Shota KatoriTakeshi Yagi
Jul 27, 2006·American Journal of Physiology. Endocrinology and Metabolism·Chia-Shan Jenny WuKathleen G Mountjoy
Jul 15, 2003·The Journal of Biological Chemistry·Krisztián A KovácsJean-René Cardinaux

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