Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case-Control Studies

Frontiers in Neurology
Salvatore TerrazzinoCristina Tassorelli

Abstract

Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship between rs6265 and migraine susceptibility. A comprehensive search was performed through PubMed, Web of Knowledge, and Cochrane databases up to October 2016. The pooled odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated to estimate the strength of the association with rs6265 under an additive, dominant, or recessive model of inheritance. A total of five studies including 1,442 cases and 1,880 controls were identified for the meta-analysis. The pooled data showed an increased risk of migraine for the allelic (OR: 1.17, 95% CI: 1.03-1.34, p = 0.014) or the dominant model of rs6265 (OR: 1.22, 95% CI: 1.05-1.41, p = 0.011). Statistical significance of rs6265 was lost when one single study was excluded from the analysis (dominant OR: 1.17, 95% CI: 1.00-1.38, p = 0.054; allelic OR: 1.14, 95% CI: 0.99-1.31, p = 0.067), suggesting lack of robustness of pooled estimates. When stratified by migra...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W ThompsonS B McMahon
Feb 1, 2002·Nature Medicine·Hayrunnisa BolayMichael A Moskowitz
Mar 27, 2002·International Journal of Epidemiology·Toshiaki A FurukawaLauren E Griffith
May 4, 2002·Nature Reviews. Genetics·Holly K TaborRichard M Myers
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 10, 2006·Nature Genetics·John P A IoannidisUNKNOWN Human Genome Epidemiology Network and the Network of Investigator Networks
Aug 26, 2006·The European Journal of Neuroscience·Anja UrbachOtto W Witte
May 15, 2008·Journal of Neural Transmission·Martin MarziniakClaudia Sommer
Jun 3, 2008·Progress in Neurobiology·Adalberto MerighiRita Bardoni
Jun 12, 2009·The Journal of Headache and Pain·Cherubino Di LorenzoFrancesco Pierelli
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael E GreenbergBarbara L Hempstead
Jun 18, 2010·The Journal of Headache and Pain·Marco Túlio A TanureRenan Barros Domingues
Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xichun ZhangRami Burstein
Oct 21, 2010·Cephalalgia : an International Journal of Headache·Carolina LemosAlda Sousa
Nov 3, 2010·Cephalalgia : an International Journal of Headache·G DemarquayP Ryvlin
Mar 1, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Iva DinchevaFrancis S Lee
May 16, 2012·The Journal of Headache and Pain·Marlene FischerGregor Broessner
May 23, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yu PeiXin Ma
Aug 21, 2012·The Journal of Pain : Official Journal of the American Pain Society·Cherubino Di LorenzoStefano Seri
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Apr 9, 2014·Headache·Heidi G SutherlandLyn R Griffiths
Dec 20, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wataru SakoRyuji Kaji
May 1, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rami BursteinDavid Borsook
Oct 27, 2015·Cephalalgia : an International Journal of Headache·M VianaC Tassorelli
Dec 22, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Kaiyuan ChenQingjun Huang
May 19, 2016·Oncotarget·Marta KowalskaJolanta Dorszewska
Jul 29, 2016·Mini Reviews in Medicinal Chemistry·Carlos M Villalón, Antoinette Maassen VanDenBrink
Aug 4, 2016·Neuropsychiatric Disease and Treatment·Salih CoskunMehmet Ugur Cevik
Aug 31, 2016·Cephalalgia : an International Journal of Headache·Michele VianaCristina Tassorelli
Nov 12, 2016·Lancet Neurology·Kjersti Grøtta Vetvik, E Anne MacGregor
Feb 6, 2017·The Journal of Headache and Pain·Xiaoying CaiYannan Fang

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

ProMeta
Quanto
Open Meta - Analyst

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