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Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain

Brain Research

Mar 17, 2000

William C CoveyRobert Nicholas Spengler

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Abstract

The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibl...read more

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Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Brain
Chronic Disease
Dose-Response Relationship, Drug
Electric Stimulation Technique
Hippocampus (Brain)
Hyperalgesia
Metabolic Inhibition
Structure of Locus Ceruleus
Paper Details
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  • References34
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Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain

Brain Research

Mar 17, 2000

William C CoveyRobert Nicholas Spengler

PMID: 10720620

DOI: 10.1016/s0006-8993(00)01965-x

Abstract

The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibl...read more

Mentioned in this Paper

Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Brain
Chronic Disease
Dose-Response Relationship, Drug

Similar Papers Found In These Feeds

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Paper Details
References
  • References34
  • Citations40
1234
  • References34
  • Citations40
1234

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