journal cover

Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant

The Journal of Pharmacology and Experimental Therapeutics

Sep 1, 2004

Jessica L ReynoldsRobert Nicholas Spengler

Get paper from

Abstract

The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine). To establish this role, field stimulation and superfusion of rat hippocampal slices was employed to investigate...read more

Mentioned in this Paper

Desipramine
Norepinephrine
Norepinephrine, (+, -)-Isomer
Tritium
Drug Kinetics
Metabolic Inhibition
Brain
Recombinants
Rats, Holtzman
Thymoleptics
Paper Details
References
  • References24
  • Citations12
123
  • References24
  • Citations12
12

Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant

The Journal of Pharmacology and Experimental Therapeutics

Sep 1, 2004

Jessica L ReynoldsRobert Nicholas Spengler

PMID: 15082752

DOI: 10.1124/jpet.104.067835

Abstract

The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine). To establish this role, field stimulation and superfusion of rat hippocampal slices was employed to investigate...read more

Mentioned in this Paper

Desipramine
Norepinephrine
Norepinephrine, (+, -)-Isomer
Tritium
Drug Kinetics

Related Papers

Paper Details
References
  • References24
  • Citations12
123
  • References24
  • Citations12
12

Get paper from

/papers/brain-derived-tumor-necrosis-factor-alpha-and-its/15082752