PMID: 3770589Aug 1, 1986Paper

Brain distribution of idebenone (CV-2619) and its effect on local cerebral glucose utilization in rats

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Y NagaiA Nagaoka

Abstract

To investigate the possible action-sites of a cerebral metabolism activator, idebenone (CV-2619), its distribution in the brain and effect on local cerebral glucose utilization (LCGU) were studied both in normal rats (WKY) and in stroke-prone spontaneously hypertensive rats (SHRSP) with cerebrovascular lesions. At 5 min after intravenous administration of [14C] CV-2619 (10 mg/kg), the distribution ratio in the brain was 0.45-0.56% of the dosage. Autoradiographic study showed that 14C levels were higher in the white matter than in the grey matter. When [14C] CV-2619 was administered orally (100 mg/kg) and intraperitoneally (30 mg/kg), 14C levels in eleven brain regions (15 min after administration) were 0.22-0.39 microgram/g (CV-2619 equivalent) and 1.11-1.30 micrograms/g, respectively, in WKY and 0.17-0.28 microgram/g and 1.66-1.87 microgram/g, respectively, in SHRSP. Total 14C levels were not markedly different among the brain regions of the rats. The analysis of unchanged CV-2619 and its metabolites revealed that unchanged CV-2619 in the cerebral cortex, thalamus and cerebellum was relatively higher than that in the other brain regions. Studies on LCGU demonstrated that CV-2619 (30 mg/kg/day, i.p., for 3 days) improved the de...Continue Reading

Citations

Nov 1, 1992·Archives of Gerontology and Geriatrics·M LingettiF Di Grazia
Nov 1, 1992·Archives of Gerontology and Geriatrics·B BergamascoR Coppi
Nov 1, 1990·Archives of Gerontology and Geriatrics·I Zs -Nagy
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·Y YamasakiY Yamori
Feb 28, 2006·Brain Research·Magdalena DraganJohn X Wilson
Jul 23, 2013·Journal of Neuroimmunology·Sebastian M FiebigerCarmen Infante-Duarte

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