PMID: 9632934Jun 20, 1998Paper

Brain eicosanoids and LPS fever: species and age differences

Progress in Brain Research
V Fraifeld, J Kaplanski

Abstract

The results of the present study, summarized in Table 2, demonstrate that different species and strains of rodents (rats and mice) and birds (chickens) exhibit rather specific fever response. Systemic administration of LPS caused monophasic elevation in Tb of chickens, biphasic changes in Tb of rats (initial drop followed by an increase in Tb), whereas mice failed to develop hyperthermia and responded by a decreased Tb. The LPS-induced alterations in hypothalamic prostanoid synthesis were also rather species-specific and differ markedly even between the two strains of mice. We failed to find a common direct correlation between LPS-induced changes in Tb and hypothalamic prostanoid production in rodents (rats and mice). This observation is supported by our recent study on age-related changes in fever response in rats, where we found that hypothalami of LPS-treated old and young adult rats produced similar amounts of PGE2 and PGI2, in spite of more pronounced and prolonged hypothermia, and a delayed elevation in Tb of old rats, as compared with young (Fraifeld et al., 1995b). Moreover, the hypothalamus of febrile chickens did not display any detectable activation of PGE2 production, suggesting that PGE2 is not a common central med...Continue Reading

Citations

Nov 8, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ana Paula Oliveira FerreiraCarlos Fernando Mello
Sep 11, 2014·Developmental Neurobiology·Deirtra HunterGordon A Barr
Jan 14, 1999·The American Journal of Physiology·L PaulJ Kaplanski
Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·M FatehiZ Fatehi-Hassanabad
Nov 11, 2003·The Japanese Journal of Physiology·Shigeki Nomoto
Sep 8, 2017·Canadian Journal of Physiology and Pharmacology·Fiona B McDonaldShabih U Hasan
Mar 28, 2013·The Journal of Experimental Biology·Silke NebelChristopher G Guglielmo
Aug 2, 2015·The Journal of Experimental Biology·Sandra Sköld-ChiriacDennis Hasselquist

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