Brain enzyme adaptation to mild normobaric intermittent hypoxia

Journal of Neuroscience Research
F MarzaticoG Benzi

Abstract

The adaptation to repeated periods of intermittent normobaric hypoxia (oxygen:nitrogen = 10:90, 12 hr daily for 5 days) of some specific enzymatic activities related to energy metabolism has been observed in different rat brain areas (cerebral cortex, hippocampus, corpus striatum, hypothalamus, cerebellum, and medulla oblongata). The evaluation of the maximum rate (Vmax) of the enzymes was carried out on: the homogenate "in toto," the nonsynaptic mitochondrial fraction, and the crude synaptosomal fraction. The adaptation to intermittent normobaric hypoxic exposure was characterized by significant modifications of some enzyme activities in the homogenate "in toto" (decrease of hexokinase activity in cerebellum), in the nonsynaptic mitochondrial fraction (increase of succinate dehydrogenase activity in corpus striatum and decrease of cytochrome oxidase activity in cerebral cortex), and, particularly, in the synaptosomal fraction (decrease of cytochrome oxidase activity in cerebral cortex, hippocampus, corpus striatum, and cerebellum, and decrease of malate dehydrogenase and lactate dehydrogenase activity in cerebellum). The adaptation to normobaric intermittent hypoxia differs according to the brain area, subcellular fraction, an...Continue Reading

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Citations

Apr 1, 1994·Neurochemical Research·G BenziR F Villa
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·B Jänicke, H Coper
Jul 1, 1994·Neurobiology of Aging·G BenziR F Villa
Aug 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·O PastorisR F Villa
Sep 16, 2020·Experimental Lung Research·Megha A NimjeBhuvnesh Kumar

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